Dual-Stage Light Amplified Photodynamic Therapy against Hypoxic Tumor Based on an O 2 Self-Sufficient Nanoplatform

Tumor hypoxia severely limits the efficacy of traditional photodynamic therapy (PDT). Here, a liposome-based nanoparticle (designated as LipoMB/CaO ) with O self-sufficient property for dual-stage light-driven PDT is demonstrated to address this problem. Through a short time irradiation, O activated...

Full description

Saved in:
Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2017-10, Vol.13 (37)
Main Authors: Liu, Li-Han, Zhang, Yao-Hui, Qiu, Wen-Xiu, Zhang, Lu, Gao, Fan, Li, Bin, Xu, Lu, Fan, Jin-Xian, Li, Zi-Hao, Zhang, Xian-Zheng
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tumor hypoxia severely limits the efficacy of traditional photodynamic therapy (PDT). Here, a liposome-based nanoparticle (designated as LipoMB/CaO ) with O self-sufficient property for dual-stage light-driven PDT is demonstrated to address this problem. Through a short time irradiation, O activated by the photosensitizer methylene blue (MB) can induce lipid peroxidation to break the liposome, and enlarge the contact area of CaO with H O, resulting in accelerated O production. Accelerated O level further regulates hypoxic tumor microenvironment and in turn improves O generation by MB under another long time irradiation. In vitro and in vivo experiments also demonstrate the superior competence of LipoMB/CaO to alleviate tumor hypoxia, suppress tumor growth and antitumor metastasis with low side-effect. The O self-sufficient LipoMB/CaO nanoplatform with dual-stage light manipulation is a successful attempt for PDT against hypoxic tumor.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201701621