Metal‐Based Nanoparticles: Mechanistic Differences in Cell Death Responses to Metal‐Based Engineered Nanomaterials in Kupffer Cells and Hepatocytes (Small 21/2020)

In article number 2000528, André E. Nel, Tian Xia, and co‐workers show how metal‐based nanoparticles are taken up by liver cells including Kupffer cells and hepatocytes, where they induce tiered oxidative stress responses including mitochondrial reactive oxygen species generation, glutathione deplet...

Full description

Saved in:
Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2020-05, Vol.16 (21), p.n/a
Main Authors: Wang, Xiang, Chang, Chong Hyun, Jiang, Jinhong, Liu, Xiangsheng, Li, Jiulong, Liu, Qi, Liao, Yu‐Pei, Li, Linjiang, Nel, André E., Xia, Tian
Format: Article
Language:English
Subjects:
hepatocytes
Kupffer cells
macrophages
nanoparticles
NLRP3 inflammasome activation
potassium efflux
pyroptosis
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c1343-97a86e06341e84d3e72c94b5c2f970a6c904e6aea3c0f8fc519b9158b2b1b5da3
cites
container_end_page n/a
container_issue 21
container_start_page
container_title Small (Weinheim an der Bergstrasse, Germany)
container_volume 16
creator Wang, Xiang
Chang, Chong Hyun
Jiang, Jinhong
Liu, Xiangsheng
Li, Jiulong
Liu, Qi
Liao, Yu‐Pei
Li, Linjiang
Nel, André E.
Xia, Tian
description In article number 2000528, André E. Nel, Tian Xia, and co‐workers show how metal‐based nanoparticles are taken up by liver cells including Kupffer cells and hepatocytes, where they induce tiered oxidative stress responses including mitochondrial reactive oxygen species generation, glutathione depletion, expression of phase II enzymes such as HO‐1, production of pro‐inflammatory cytokines including IL‐1β and TNF‐α, and cell death via different mechanisms including apoptosis (Ag, CuO, ZnO, V2O5) and pyroptosis (fumed SiO2).
doi_str_mv 10.1002/smll.202070113
format article
fullrecord <record><control><sourceid>wiley_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1002_smll_202070113</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>SMLL202070113</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1343-97a86e06341e84d3e72c94b5c2f970a6c904e6aea3c0f8fc519b9158b2b1b5da3</originalsourceid><addsrcrecordid>eNqFkEtOwzAQhiMEElDYsvYSFmn9yMvsoC0UkYJEYR1NnAk1ch6Kg1B3HIFbcC9OQtKiIlasZsby943md5wTRoeMUj6yhTFDTjkNKWNixzlgARNuEHG5u-0Z3XcOrX2hVDDuhQfO5xxbMF_vH5dgMSN3UFY1NK1WBu05maNaQqltN5OJznNssFRoiS7JGI0hE4R2SR7Q1lVpu_e2In990_JZl9hhG3UBLTYazNpw-1r3xrXJEigzMsMa2kqt2k51uiig28DZqD_p7MjZyzsOj3_qwHm6mj6OZ258f30zvohdxYQnXBlCFCANhMcw8jKBIVfSS33FcxlSCJSkHgaAIBTNo1z5TKaS-VHKU5b6GYiBM9x4VVNZ22Ce1I0uoFkljCZ9zEkfc7KNuQPkBnjTBlf__E4W8zj-Zb8BMFeFKw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Metal‐Based Nanoparticles: Mechanistic Differences in Cell Death Responses to Metal‐Based Engineered Nanomaterials in Kupffer Cells and Hepatocytes (Small 21/2020)</title><source>Wiley</source><creator>Wang, Xiang ; Chang, Chong Hyun ; Jiang, Jinhong ; Liu, Xiangsheng ; Li, Jiulong ; Liu, Qi ; Liao, Yu‐Pei ; Li, Linjiang ; Nel, André E. ; Xia, Tian</creator><creatorcontrib>Wang, Xiang ; Chang, Chong Hyun ; Jiang, Jinhong ; Liu, Xiangsheng ; Li, Jiulong ; Liu, Qi ; Liao, Yu‐Pei ; Li, Linjiang ; Nel, André E. ; Xia, Tian</creatorcontrib><description>In article number 2000528, André E. Nel, Tian Xia, and co‐workers show how metal‐based nanoparticles are taken up by liver cells including Kupffer cells and hepatocytes, where they induce tiered oxidative stress responses including mitochondrial reactive oxygen species generation, glutathione depletion, expression of phase II enzymes such as HO‐1, production of pro‐inflammatory cytokines including IL‐1β and TNF‐α, and cell death via different mechanisms including apoptosis (Ag, CuO, ZnO, V2O5) and pyroptosis (fumed SiO2).</description><identifier>ISSN: 1613-6810</identifier><identifier>EISSN: 1613-6829</identifier><identifier>DOI: 10.1002/smll.202070113</identifier><language>eng</language><subject>hepatocytes ; Kupffer cells ; macrophages ; nanoparticles ; NLRP3 inflammasome activation ; potassium efflux ; pyroptosis</subject><ispartof>Small (Weinheim an der Bergstrasse, Germany), 2020-05, Vol.16 (21), p.n/a</ispartof><rights>2020 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1343-97a86e06341e84d3e72c94b5c2f970a6c904e6aea3c0f8fc519b9158b2b1b5da3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Wang, Xiang</creatorcontrib><creatorcontrib>Chang, Chong Hyun</creatorcontrib><creatorcontrib>Jiang, Jinhong</creatorcontrib><creatorcontrib>Liu, Xiangsheng</creatorcontrib><creatorcontrib>Li, Jiulong</creatorcontrib><creatorcontrib>Liu, Qi</creatorcontrib><creatorcontrib>Liao, Yu‐Pei</creatorcontrib><creatorcontrib>Li, Linjiang</creatorcontrib><creatorcontrib>Nel, André E.</creatorcontrib><creatorcontrib>Xia, Tian</creatorcontrib><title>Metal‐Based Nanoparticles: Mechanistic Differences in Cell Death Responses to Metal‐Based Engineered Nanomaterials in Kupffer Cells and Hepatocytes (Small 21/2020)</title><title>Small (Weinheim an der Bergstrasse, Germany)</title><description>In article number 2000528, André E. Nel, Tian Xia, and co‐workers show how metal‐based nanoparticles are taken up by liver cells including Kupffer cells and hepatocytes, where they induce tiered oxidative stress responses including mitochondrial reactive oxygen species generation, glutathione depletion, expression of phase II enzymes such as HO‐1, production of pro‐inflammatory cytokines including IL‐1β and TNF‐α, and cell death via different mechanisms including apoptosis (Ag, CuO, ZnO, V2O5) and pyroptosis (fumed SiO2).</description><subject>hepatocytes</subject><subject>Kupffer cells</subject><subject>macrophages</subject><subject>nanoparticles</subject><subject>NLRP3 inflammasome activation</subject><subject>potassium efflux</subject><subject>pyroptosis</subject><issn>1613-6810</issn><issn>1613-6829</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkEtOwzAQhiMEElDYsvYSFmn9yMvsoC0UkYJEYR1NnAk1ch6Kg1B3HIFbcC9OQtKiIlasZsby943md5wTRoeMUj6yhTFDTjkNKWNixzlgARNuEHG5u-0Z3XcOrX2hVDDuhQfO5xxbMF_vH5dgMSN3UFY1NK1WBu05maNaQqltN5OJznNssFRoiS7JGI0hE4R2SR7Q1lVpu_e2In990_JZl9hhG3UBLTYazNpw-1r3xrXJEigzMsMa2kqt2k51uiig28DZqD_p7MjZyzsOj3_qwHm6mj6OZ258f30zvohdxYQnXBlCFCANhMcw8jKBIVfSS33FcxlSCJSkHgaAIBTNo1z5TKaS-VHKU5b6GYiBM9x4VVNZ22Ce1I0uoFkljCZ9zEkfc7KNuQPkBnjTBlf__E4W8zj-Zb8BMFeFKw</recordid><startdate>20200526</startdate><enddate>20200526</enddate><creator>Wang, Xiang</creator><creator>Chang, Chong Hyun</creator><creator>Jiang, Jinhong</creator><creator>Liu, Xiangsheng</creator><creator>Li, Jiulong</creator><creator>Liu, Qi</creator><creator>Liao, Yu‐Pei</creator><creator>Li, Linjiang</creator><creator>Nel, André E.</creator><creator>Xia, Tian</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20200526</creationdate><title>Metal‐Based Nanoparticles: Mechanistic Differences in Cell Death Responses to Metal‐Based Engineered Nanomaterials in Kupffer Cells and Hepatocytes (Small 21/2020)</title><author>Wang, Xiang ; Chang, Chong Hyun ; Jiang, Jinhong ; Liu, Xiangsheng ; Li, Jiulong ; Liu, Qi ; Liao, Yu‐Pei ; Li, Linjiang ; Nel, André E. ; Xia, Tian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1343-97a86e06341e84d3e72c94b5c2f970a6c904e6aea3c0f8fc519b9158b2b1b5da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>hepatocytes</topic><topic>Kupffer cells</topic><topic>macrophages</topic><topic>nanoparticles</topic><topic>NLRP3 inflammasome activation</topic><topic>potassium efflux</topic><topic>pyroptosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xiang</creatorcontrib><creatorcontrib>Chang, Chong Hyun</creatorcontrib><creatorcontrib>Jiang, Jinhong</creatorcontrib><creatorcontrib>Liu, Xiangsheng</creatorcontrib><creatorcontrib>Li, Jiulong</creatorcontrib><creatorcontrib>Liu, Qi</creatorcontrib><creatorcontrib>Liao, Yu‐Pei</creatorcontrib><creatorcontrib>Li, Linjiang</creatorcontrib><creatorcontrib>Nel, André E.</creatorcontrib><creatorcontrib>Xia, Tian</creatorcontrib><collection>CrossRef</collection><jtitle>Small (Weinheim an der Bergstrasse, Germany)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xiang</au><au>Chang, Chong Hyun</au><au>Jiang, Jinhong</au><au>Liu, Xiangsheng</au><au>Li, Jiulong</au><au>Liu, Qi</au><au>Liao, Yu‐Pei</au><au>Li, Linjiang</au><au>Nel, André E.</au><au>Xia, Tian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metal‐Based Nanoparticles: Mechanistic Differences in Cell Death Responses to Metal‐Based Engineered Nanomaterials in Kupffer Cells and Hepatocytes (Small 21/2020)</atitle><jtitle>Small (Weinheim an der Bergstrasse, Germany)</jtitle><date>2020-05-26</date><risdate>2020</risdate><volume>16</volume><issue>21</issue><epage>n/a</epage><issn>1613-6810</issn><eissn>1613-6829</eissn><abstract>In article number 2000528, André E. Nel, Tian Xia, and co‐workers show how metal‐based nanoparticles are taken up by liver cells including Kupffer cells and hepatocytes, where they induce tiered oxidative stress responses including mitochondrial reactive oxygen species generation, glutathione depletion, expression of phase II enzymes such as HO‐1, production of pro‐inflammatory cytokines including IL‐1β and TNF‐α, and cell death via different mechanisms including apoptosis (Ag, CuO, ZnO, V2O5) and pyroptosis (fumed SiO2).</abstract><doi>10.1002/smll.202070113</doi><tpages>1</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1613-6810
ispartof Small (Weinheim an der Bergstrasse, Germany), 2020-05, Vol.16 (21), p.n/a
issn 1613-6810
1613-6829
language eng
recordid cdi_crossref_primary_10_1002_smll_202070113
source Wiley
subjects hepatocytes
Kupffer cells
macrophages
nanoparticles
NLRP3 inflammasome activation
potassium efflux
pyroptosis
title Metal‐Based Nanoparticles: Mechanistic Differences in Cell Death Responses to Metal‐Based Engineered Nanomaterials in Kupffer Cells and Hepatocytes (Small 21/2020)
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T22%3A03%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wiley_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Metal%E2%80%90Based%20Nanoparticles:%20Mechanistic%20Differences%20in%20Cell%20Death%20Responses%20to%20Metal%E2%80%90Based%20Engineered%20Nanomaterials%20in%20Kupffer%20Cells%20and%20Hepatocytes%20(Small%2021/2020)&rft.jtitle=Small%20(Weinheim%20an%20der%20Bergstrasse,%20Germany)&rft.au=Wang,%20Xiang&rft.date=2020-05-26&rft.volume=16&rft.issue=21&rft.epage=n/a&rft.issn=1613-6810&rft.eissn=1613-6829&rft_id=info:doi/10.1002/smll.202070113&rft_dat=%3Cwiley_cross%3ESMLL202070113%3C/wiley_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c1343-97a86e06341e84d3e72c94b5c2f970a6c904e6aea3c0f8fc519b9158b2b1b5da3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true