Spatial Genomics: Mapping Spatial Genetic Landscapes in Tissue Sections through Microscale Integration of Sampling Methodology into Genomic Workflows (Small 23/2021)

The GeneScape workflow, presented in article number 2007901 by Govind V. Kaigala and co‐workers, uses a modular multipurpose microfluidic probe to facilitate evaluation of spatial genomic heterogeneity in tumors. Cancer cells essentially contain the same genomic blueprint but accumulate distinct cor...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2021-06, Vol.17 (23), p.n/a
Main Authors: Voith von Voithenberg, Lena, Kashyap, Aditya, Opitz, Lennart, Aquino, Catharine, Sykes, Timothy, Nieser, Maike, Petrini, Lorenzo F. T., Enrriquez Casimiro, Nadia, Kooten, Xander F., Biskup, Saskia, Schlapbach, Ralph, Schraml, Peter, Kaigala, Govind V.
Format: Article
Language:English
Subjects:
microfluidic probe
next generation sequencing
spatial genomics
tumor heterogeneity
Online Access:Get full text
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Summary:The GeneScape workflow, presented in article number 2007901 by Govind V. Kaigala and co‐workers, uses a modular multipurpose microfluidic probe to facilitate evaluation of spatial genomic heterogeneity in tumors. Cancer cells essentially contain the same genomic blueprint but accumulate distinct corruptions at different spatial and temporal coordinates. Since these cells reside in several interacting ecosystems, it becomes very critical to study the spatial mutational landscape to evaluate and quantify tumor progression.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.202170112