Advancing COVID‐19 Diagnosis: Enhancement in SERS‐PCR with 30‐nm Au Nanoparticle‐Internalized Nanodimpled Substrates (Small 46/2024)

Molecular Diagnostic Systems Using an Au nanoparticles‐Au nanodimples (AuNPs‐AuNDPs) substrate, in article number 2403672, Sang‐Woo Joo, Sung‐Gyu Park, Jaebum Choo, and co‐workers developed a highly sensitive surface‐enhanced Raman scattering (SERS)‐polymerase chain reaction molecular diagnostic ass...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2024-11, Vol.20 (46), p.n/a
Main Authors: Dang, Hajun, Joung, Younju, Yang, Jun‐Yeong, Lee, Soo Hyun, Lee, Seunghun, Joo, Sang‐Woo, Park, Sung‐Gyu, Choo, Jaebum
Format: Article
Language:English
Subjects:
Au nanoparticle
nanodimpled substrate
plasmonic coupling
real‐time polymerase chain reaction
surface‐enhanced Raman scattering
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Summary:Molecular Diagnostic Systems Using an Au nanoparticles‐Au nanodimples (AuNPs‐AuNDPs) substrate, in article number 2403672, Sang‐Woo Joo, Sung‐Gyu Park, Jaebum Choo, and co‐workers developed a highly sensitive surface‐enhanced Raman scattering (SERS)‐polymerase chain reaction molecular diagnostic assay platform capable of detecting 105 copies/μL of the SARS‐CoV‐2 target gene with a minimal number of thermocycles. These results are expected to ultimately lay the foundation for developing SERS‐based amplification‐free molecular diagnostic systems.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.202470336