Study of chromosome damage in patients with breast cancer treated by two antineoplastic treatments

• Published in: Teratogenesis, carcinogenesis, and mutagenesis carcinogenesis, and mutagenesis, 2002, Vol.22 (4), p.257-269
• Main Authors: Silva, L.M., Takahashi, C.S., Carrara, H.H.A.
• Format: Article
• Language: English
• Subjects: Adult; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - pharmacology; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Carcinoma, Ductal, Breast - drug therapy; Carcinoma, Ductal, Breast - genetics; Carcinoma, Ductal, Breast - pathology; Carcinoma, Lobular - drug therapy; Carcinoma, Lobular - genetics; Carcinoma, Lobular - pathology; Cell Division - drug effects; chemotherapy; chromosome aberrations; Chromosome Aberrations - drug effects; Chromosomes, Human - drug effects; Chromosomes, Human - ultrastructure; Cyclophosphamide - administration & dosage; Cyclophosphamide - pharmacology; DNA Damage; Drug Administration Schedule; Drug toxicity and drugs side effects treatment; Epirubicin - administration & dosage; Epirubicin - pharmacology; Female; Fluorouracil - administration & dosage; Fluorouracil - pharmacology; Gynecology. Andrology. Obstetrics; Humans; Mammary gland diseases; Medical sciences; Methotrexate - administration & dosage; Methotrexate - pharmacology; Middle Aged; Miscellaneous (drug allergy, mutagens, teratogens...); Mitotic Index; Pharmacology. Drug treatments; proliferative index; Sister Chromatid Exchange - drug effects; sister chromatid exchanges; Tumors
• ISSN: 0270-3211; 1520-6866
• DOI: 10.1002/tcm.10019

The frequencies of chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) were determined in peripheral blood lymphocyte cultures from women with breast cancer treated by chemotherapy (CT) with FEC (5‐fluorouracil, epirubicin, and cyclophosphamide) or CMF (cyclophosphamide, methotrexate, and 5‐fluorouracil) cocktail in six CT cycles. The number of patients in each CT cycle were from 1 to 3 for SCE and 2 to 5 for CA. Samples were collected before and 48 h after CT. Although the size of the sample was limited and interindividual variability was wide, it appears that a 21‐day interval between CT sessions is sufficient for cell recovery. This fact was demonstrated by the reduction in CA and SCE frequencies between cycles in parallel with the unchanged mitotic index and proliferative index values. © 2002 Wiley‐Liss, Inc.