Calcification of the mesenteric veins suspected of idiopathic mesenteric phlebosclerosis associated with long‐term herbal medicine ‘inchinkoto’ prescribed for biliary atresia: A multicenter study

• Published in: Traditional & Kampo medicine 2024-12, Vol.11 (3), p.208-213
• Main Authors: Hashizume, Naoki, Sugita, Koshiro, Masui, Daisuke, Sakamoto, Saki, Kawano, Takafumi, Harumatsu, Toshio, Masuya, Ryuta, Onishi, Shun, Higashidate, Naruki, Koga, Yoshinori, Egami, Hideaki, Ieiri, Satoshi, Kaji, Tatsuru
• Format: Article
• Language: English
• Subjects: biliary atresia; Gardeniae fructus; idiopathic mesenteric phlebosclerosis; Inchinkoto
• ISSN: 2053-4515; 2053-4515
• DOI: 10.1002/tkm2.1428

Aim Inchinkoto (ICKT) is administered to patients with biliary atresia (BA) after surgery. Gardeniae fructus which is contained in ICKT is reported to be associated with idiopathic mesenteric phlebosclerosis (IMP). We investigated the influence of ICKT on calcification of the mesenteric veins suspected of IMP in BA patients. Methods All BA patients with native liver survival who received ICKT after Kasai portoenterostomy were reviewed. All patients underwent abdominal computed tomography (CT) during treatment. Calcification of the mesenteric veins on the most recent CT scan after the initiation of ICKT was assessed. Results Twenty patients (6 males and 14 females) were enrolled in this study. Of these patients, 17 (85.0%) and 10 (50%) patients had used ICKT for ≥5 years and >10 years, respectively. Calcification of the mesenteric veins was detected in one patient, who was a 14 year old girl. The total dosage of Gardeniae fructus was 21 800 g. Conclusions The incidence of calcification of the mesenteric veins in BA patients receiving ICKT was low. However, it is necessary to be aware that ICKT containing Gardeniae fructus is associated with the risk of developing calcification of the mesenteric veins suspected of IMP.