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Embryotoxic and teratogenic effects of pesticides in chick embryos: A comparative study using two commercial formulations

Developmental toxicity of two different classes of commercial formulations of insecticides was studied by in ovo treatment of fertilized Rhode Island Red eggs. The first one was a combination of chlorpyrifos and cypermethrin and the second one was spinosad, a fermentation product of soil bacterium,...

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Bibliographic Details
Published in:Environmental toxicology 2012-03, Vol.27 (3), p.166-174
Main Authors: Uggini, Gowri K., Patel, Prabhudas V., Balakrishnan, Suresh
Format: Article
Language:English
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Summary:Developmental toxicity of two different classes of commercial formulations of insecticides was studied by in ovo treatment of fertilized Rhode Island Red eggs. The first one was a combination of chlorpyrifos and cypermethrin and the second one was spinosad, a fermentation product of soil bacterium, Actinomycetes. In this study, the combination pesticide and spinosad of different concentrations were administered as a single dose in ovo in volumes of 50 μL per each egg on day “0” of incubation. Embryonic growth and development, morphological and skeletal malformations, and hatchability were assessed. The combination insecticide induced explicit alterations in the embryonic growth and development and resulted in malformations particularly to the axial and appendicular skeletal structures, whereas the changes were trivial in case of the spinosad exposure. © 2010 Wiley Periodicals, Inc. Environ Toxicol, 2012.
ISSN:1520-4081
1522-7278
DOI:10.1002/tox.20627