Back Cover: The PES1/FOXM1 heterodimer suppresses TCF21 and ERβ expression in ovarian endometriosis (View 1/2024)

In article number 20230090, Qing Xue and her co‐workers have display that transcription factor 21 (TCF21) and estrogen receptor beta (ERβ, encoded by ESR2) are the key factors in the pathogenesis of endometriosis, but their co‐regulation mechanism is still unknown. PES1 is downregulated in ectopic l...

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Bibliographic Details
Published in:View (Beijing, China) China), 2024-02, Vol.5 (1), p.n/a
Main Authors: Zhu, Jingwen, Wu, Peili, Lu, Ruihui, Zeng, Cheng, Peng, Chao, Zhou, Yingfang, Xue, Qing
Format: Article
Language:English
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Summary:In article number 20230090, Qing Xue and her co‐workers have display that transcription factor 21 (TCF21) and estrogen receptor beta (ERβ, encoded by ESR2) are the key factors in the pathogenesis of endometriosis, but their co‐regulation mechanism is still unknown. PES1 is downregulated in ectopic lesions. PES1 reduces the stability of the FOXM1 protein and weakens the transcriptional inhibition of ERβ and TCF21 by FOXM1. Overexpression of PES1 could effectively suppress the growth of ectopic lesions in mice indicating that PES1 has therapeutic potential for endometriosis.
ISSN:2688-3988
2688-268X
2688-268X
DOI:10.1002/viw2.341