An investigation on the relevance of prolactin, insulin-like growth factor-1 and 25-hydroxyvitamin D 3 (25-OHD 3 ) in canine benign prostatic hyperplasia in a predisposed breed model

Serum concentrations of prolactin (PRL), insulin-like growth factor-1 (IGF-1) and 25 hydroxyvitamin D (25-OHD ) were analysed to investigate their possible involvement in the pathogenesis of benign prostatic hyperplasia (BPH). For this, dogs of the Rhodesian Ridgeback (RR) breed were used because of...

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Bibliographic Details
Published in:Veterinary medicine and science 2021-09, Vol.7 (5), p.1493-1503
Main Authors: Werhahn Beining, Franziska, Schmicke, Marion, Wilkens, Mirja, Wolf, Karola, Rohn, Karl, Günzel-Apel, Anne-Rose
Format: Article
Language:English
Subjects:
Animals
Calcifediol - therapeutic use
Dog Diseases - diagnosis
Dogs
Insulin-Like Growth Factor I
Male
Prolactin - therapeutic use
Prostatic Hyperplasia - diagnosis
Prostatic Hyperplasia - veterinary
Vitamin D - analogs & derivatives
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Summary:Serum concentrations of prolactin (PRL), insulin-like growth factor-1 (IGF-1) and 25 hydroxyvitamin D (25-OHD ) were analysed to investigate their possible involvement in the pathogenesis of benign prostatic hyperplasia (BPH). For this, dogs of the Rhodesian Ridgeback (RR) breed were used because of a verified breed disposition for the development of BPH. Labrador Retrievers (LR) served as controls. The prostate gland status was characterised by the prostate gland volume, clinical signs of BPH (haemospermia and sonographic findings) and the plasma concentration of canine prostate-specific arginine esterase (CPSE). Breed specificity in the RR was expressed by a correlation of PRL with breed (p 
ISSN:2053-1095
2053-1095
DOI:10.1002/vms3.514