Novel Biological Functions of Interleukin-4: Formation of Tube-like Structures by Vascular Endothelial Cellsin Vitroand Angiogenesisin Vivo

The effect of interleukin-4 (IL-4) on angiogenesis was studiedin vitroandin vivo. Human recombinant IL-4 significantly stimulated the formation of tube-like structures in collagen gels by bovine aortic endothelial cells as well as by human microvascular endothelial cells. Human recombinant IL-4 at 5...

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Published in:Biochemical and biophysical research communications 1998-09, Vol.250 (2), p.444-448
Main Authors: Fukushi, Jun-ichi, Morisaki, Takashi, Shono, Tadahisa, Nishie, Akihiro, Torisu, Hitoe, Ono, Mayumi, Kuwano, Michihiko
Format: Article
Language:English
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Summary:The effect of interleukin-4 (IL-4) on angiogenesis was studiedin vitroandin vivo. Human recombinant IL-4 significantly stimulated the formation of tube-like structures in collagen gels by bovine aortic endothelial cells as well as by human microvascular endothelial cells. Human recombinant IL-4 at 50–500 U/ml stimulated by about two- to threefold the formation of tubes by bovine aortic endothelial cells; the rate was comparable to that of basic fibroblast growth factor. Tube formation was almost completely inhibited by the addition of IL-4 receptor neutralizing antibody. Administration of rat recombinant IL-4 led to neovascularization when implanted in the rat cornea. Findings suggest that IL-4 may be a mediator of the immune system as well as an inducer of angiogenesis.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1998.9334