Identification of a NovelDrosophilaSMAD on the X Chromosome

TGF-β signaling from the cell surface to the nucleus is mediated by the SMAD family of proteins, which have been grouped into three classes based upon sequence identity and function. Receptor-regulated, or pathway-restricted, SMADs (R-SMADs) are phosphorylated by ligand-specific serine/threonine kin...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 1998-11, Vol.252 (1), p.195-201
Main Authors: Henderson, Katya D., Andrew, Deborah J.
Format: Article
Language:English
Subjects:
ACTIVIN
DPP
Drosophila
SMADs
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Summary:TGF-β signaling from the cell surface to the nucleus is mediated by the SMAD family of proteins, which have been grouped into three classes based upon sequence identity and function. Receptor-regulated, or pathway-restricted, SMADs (R-SMADs) are phosphorylated by ligand-specific serine/threonine kinase receptors. Phosphorylated R-SMADs oligomerize with the coactivating, or shared, SMAD (Co-SMAD) mediator and translocate to the nucleus where the complex directs transcription of downstream target genes. Inhibitory SMADs (I-SMADs) block receptor-mediated phosphorylation of R-SMADs. In Drosophila, one member of each class of SMAD has been reported: MAD, an R-SMAD, MEDEA, a Co-SMAD, and DAD, an I-SMAD. Here, we report the first identification of a novelDrosophilaR-SMAD, which we have namedSmoxforSmad on X.We have localized theSmoxgene to a specific interval on the X chromosome and shown thatSmoxis transcribed throughout development.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1998.9562