Bioavailability of Ferulic Acid

There is a wealth of evidence for the powerful antioxidant propertiesin vitroof flavonoid components of the diet. However, few studies have been undertaken concerning the hydroxycinnamates, major constituents of fruit, some vegetables, beverages, and grains, particularly the extent to which they are...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 1998-12, Vol.253 (2), p.222-227
Main Authors: Bourne, Louise C., Rice-Evans, Catherine
Format: Article
Language:English
Subjects:
Adult
antioxidant
Antioxidants - pharmacokinetics
bioavailability
Biological Availability
Caffeic Acids - metabolism
Chlorogenic Acid - metabolism
Chromatography, High Pressure Liquid
Coumaric Acids - metabolism
Coumaric Acids - pharmacokinetics
Coumaric Acids - urine
Female
ferulic acid
free radical
Humans
hydroxycinnamate
Lycopersicon esculentum - chemistry
Male
oxidation
Phenols - analysis
Plant Extracts - analysis
Propionates
tomato
urinary excretion
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Summary:There is a wealth of evidence for the powerful antioxidant propertiesin vitroof flavonoid components of the diet. However, few studies have been undertaken concerning the hydroxycinnamates, major constituents of fruit, some vegetables, beverages, and grains, particularly the extent to which they are absorbedin vivofrom the diet. The study described here has investigated the bioavailability of ferulic acid in humans, from tomato consumption, through the monitoring of the pharmacokinetics of excretion in relation to intake. The results show that the peak time for maximal urinary excretion is approximately 7 h and the recovery of ferulic acid in the urine, on the basis of total free ferulic acid and feruloyl glucuronide excreted, is 11–25% of that ingested.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1998.9681