Uncoupling Protein 3 and Peroxisome Proliferator-Activated Receptor γ2 Contribute to Obesity and Diabetes in Palauans

• Published in: Biochemical and biophysical research communications 2001-03, Vol.281 (3), p.772-778
• Main Authors: Yanagisawa, Yoshiko, Hasegawa, Kyoko, Dever, Gregory J., Otto, Caleb Tyn.O., Sakuma, Mitsuru, Shibata, Shigeo, Miyagi, Shigeji, Kaneko, Yoshinori, Kagawa, Yasuo
• Format: Article
• Language: English
• ISSN: 0006-291X; 1090-2104
• DOI: 10.1006/bbrc.2001.4417

We examined the genetic contribution of single nucleotide polymorphisms (SNPs) of the energy metabolism-related genes, including beta 3 adrenergic receptor (β3AR), apolipoprotein E (apo-E), promoter of uncoupling protein 3 (UCP3-p), peroxisome proliferator-activated receptor gamma 2 (PPARγ2) and leptin receptor (LEPR) to metabolic disorders, in 118 inhabitants of Palau. The data were statistically analyzed and ethnically compared to correlate SNPs and their metabolic parameters. UCP3-p (P < 0.01) and PPARγ2 (p = 0.05) correlated with plasma HbA1c, and UCP3-p correlated with fasting blood glucose (P < 0.01) in males, but not in females. UCP3-p correlated with body fat (%) (P < 0.01) in females, but not in males. Plasma leptin levels and apo-E were correlated in both groups. The frequency of SNPs for PPARγ2, LEPR, and UCP3-p are significantly different between Palauans and Caucasians.