Somatostatin Type V Receptor Activates c-Jun N-Terminal Kinases via Gα12 Family G Proteins

Somatostatin is a neurotransmitter with diverse effects including anti-proliferation in a wide range of normal and neoplastic cells, and occasionally growth stimulatory and neurotrophic actions. Stress-activated protein kinase or c-Jun N-terminal kinase (SAPK/JNK) can also induce growth arrest and o...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2001-12, Vol.289 (5), p.1211-1217
Main Authors: Komatsuzaki, Katsumi, Terashita, Kenzo, Kinane, T.Bernard, Nishimoto, Ikuo
Format: Article
Language:English
Subjects:
c-Jun N-terminal kinases
G12 family G proteins
somatostatin
somatostatin receptor type V
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Summary:Somatostatin is a neurotransmitter with diverse effects including anti-proliferation in a wide range of normal and neoplastic cells, and occasionally growth stimulatory and neurotrophic actions. Stress-activated protein kinase or c-Jun N-terminal kinase (SAPK/JNK) can also induce growth arrest and occasionally growth stimulation. However, the relationship between somatostatin and SAPK/JNK is less clear. Here we report that the binding of somatostatin to the somatostatin receptor type V (SSTR5) upregulates SAPK/JNK activity. We also show that this activation is mediated by Gα12 and Gα13. This study demonstrates that SSTR5 is the heptahelical receptor that activates SAPK/JNK via the G12 family G proteins.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.2001.6085