Histamine Enhanced the TNF-α-Induced Expression of E-Selectin and ICAM-1 on Vascular Endothelial Cells

Cell adhesion molecules are expressed on endothelial cells by various proinflammatory cytokines. Tumor necrosis factor-α (TNF-α) induces the expression of E-selectin and intercellular adhesion molecule-1 (ICAM-1) on human umbilical vein endothelial cells (HUVEC). Although histamine is a potent vasoa...

Full description

Saved in:
Bibliographic Details
Published in:Cellular immunology 1996-08, Vol.171 (2), p.285-288
Main Authors: Miki, Ichiro, Kusano, Akira, Ohta, So, Hanai, Nobuo, Otoshi, Masanari, Masaki, Shigehiro, Sato, Soichiro, Ohmori, Kenji
Format: Article
Language:English
Subjects:
Animals
Cells, Cultured
CHO Cells
Cricetinae
Dibenzoxepins - pharmacology
Diphenhydramine - pharmacology
Drug Interactions
E-Selectin - biosynthesis
Endothelium, Vascular - cytology
Endothelium, Vascular - drug effects
Endothelium, Vascular - immunology
Histamine - pharmacology
Histamine H1 Antagonists - pharmacology
Histamine H2 Antagonists - pharmacology
Humans
Intercellular Adhesion Molecule-1 - biosynthesis
Ketotifen - pharmacology
Olopatadine Hydrochloride
Pyrilamine - pharmacology
Ranitidine - pharmacology
Tumor Necrosis Factor-alpha - pharmacology
Umbilical Veins
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cell adhesion molecules are expressed on endothelial cells by various proinflammatory cytokines. Tumor necrosis factor-α (TNF-α) induces the expression of E-selectin and intercellular adhesion molecule-1 (ICAM-1) on human umbilical vein endothelial cells (HUVEC). Although histamine is a potent vasoactive mediator, it does not induce the expression of E-selectin and ICAM-1. In this report, we show that histamine concentration-dependently enhances the TNF-α-induced expression of E-selectin and ICAM-1 on HUVEC. The histamine-enhanced expression of E-selectin and ICAM-1 was inhibited by the histamine H1receptor antagonists, mepyramine and diphenhydramine. KW-4679 and ketotifen, antiallergic drugs with histamine H1receptor antagonistic activity, potently inhibit the expression of E-selectin and ICAM-1. A histamine H2receptor antagonist, ranitidine, did not affect the histamine-induced expression of cell adhesion molecules. These data indicate that histamine induces the expression of E-selectin and ICAM-1 synergistically with TNF-α through histamine H1receptors.
ISSN:0008-8749
1090-2163
DOI:10.1006/cimm.1996.0205