Lymphocyte Muscarinic Cholinergic Activity and PGE2Involvement in ExperimentalTrypanosoma cruziInfection

In this paper, we demonstrated that the production of PGE2by CD8+T lymphocytes through muscarinic cholinergic receptor (mAChR) activation of lymphocytes from mice acutely infected with nonlethalTrypanosoma cruziCA-1 strain could enhance resistance to infection. Treatmentin vivowith either atropine o...

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Bibliographic Details
Published in:Clinical immunology and immunopathology 1996-11, Vol.81 (2), p.122-128
Main Authors: Sterin-Borda, Leonor, Gorelik, Gabriela, Goren, Nora, Cappa, Stella Gonzalez, Celentano, Ana M., Borda, Enri
Format: Article
Language:English
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Summary:In this paper, we demonstrated that the production of PGE2by CD8+T lymphocytes through muscarinic cholinergic receptor (mAChR) activation of lymphocytes from mice acutely infected with nonlethalTrypanosoma cruziCA-1 strain could enhance resistance to infection. Treatmentin vivowith either atropine or cyclooxygenase inhibitors enhanced mortality rates and parasitemia of mice infected withT. cruziCA-1 strain. The mechanism by which CD8+T lymphocytes released PGE2appears to involve the activation of the cells by circulating IgG present in mice infected withT. cruziCA-1 strain. Binding of these antibodies to mAChR on CD8+T lymphocytes triggered the release of large amounts of PGE2. The results point to a role of serum antibodies against mAChR in the protection ofT. cruziinfection. The prostanoid acting as an immunomodulator contributed to the maintenance of the chronic course of experimental Chagas disease.
ISSN:0090-1229
1090-2341
DOI:10.1006/clin.1996.0167