Lymphocyte Muscarinic Cholinergic Activity and PGE2Involvement in ExperimentalTrypanosoma cruziInfection

In this paper, we demonstrated that the production of PGE2by CD8+T lymphocytes through muscarinic cholinergic receptor (mAChR) activation of lymphocytes from mice acutely infected with nonlethalTrypanosoma cruziCA-1 strain could enhance resistance to infection. Treatmentin vivowith either atropine o...

Full description

Saved in:
Bibliographic Details
Published in:Clinical immunology and immunopathology 1996-11, Vol.81 (2), p.122-128
Main Authors: Sterin-Borda, Leonor, Gorelik, Gabriela, Goren, Nora, Cappa, Stella Gonzalez, Celentano, Ana M., Borda, Enri
Format: Article
Language:English
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c1337-999dcc66e9def814220bb2170ce2b7ca66a2962b64c8bbb4b06a7a8febf1d4083
cites
container_end_page 128
container_issue 2
container_start_page 122
container_title Clinical immunology and immunopathology
container_volume 81
creator Sterin-Borda, Leonor
Gorelik, Gabriela
Goren, Nora
Cappa, Stella Gonzalez
Celentano, Ana M.
Borda, Enri
description In this paper, we demonstrated that the production of PGE2by CD8+T lymphocytes through muscarinic cholinergic receptor (mAChR) activation of lymphocytes from mice acutely infected with nonlethalTrypanosoma cruziCA-1 strain could enhance resistance to infection. Treatmentin vivowith either atropine or cyclooxygenase inhibitors enhanced mortality rates and parasitemia of mice infected withT. cruziCA-1 strain. The mechanism by which CD8+T lymphocytes released PGE2appears to involve the activation of the cells by circulating IgG present in mice infected withT. cruziCA-1 strain. Binding of these antibodies to mAChR on CD8+T lymphocytes triggered the release of large amounts of PGE2. The results point to a role of serum antibodies against mAChR in the protection ofT. cruziinfection. The prostanoid acting as an immunomodulator contributed to the maintenance of the chronic course of experimental Chagas disease.
doi_str_mv 10.1006/clin.1996.0167
format article
fullrecord <record><control><sourceid>elsevier_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1006_clin_1996_0167</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0090122996901671</els_id><sourcerecordid>S0090122996901671</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1337-999dcc66e9def814220bb2170ce2b7ca66a2962b64c8bbb4b06a7a8febf1d4083</originalsourceid><addsrcrecordid>eNp1kLFOwzAURS0EEqWwMvsHEmwncuKxqkqpVARDmS3beaFGqR3ZaUT4ehyVlendN5yrq4PQIyU5JYQ_mc66nArBc0J5dYUWlAiSsaKk12hB5kwZE7foLsYvkoCSVAt03E-n_ujNNAB-PUejgnXW4PXRpzYInymvzGBHO0xYuQa_bzds50bfjXACN2Dr8Oa7h2DnT3WHMPXK-ehPCptw_rE710LivbtHN63qIjz83SX6eN4c1i_Z_m27W6_2maFFUWVCiMYYzkE00Na0ZIxozWhFDDBdGcW5YoIzzUtTa61LTbiqVN2CbmlTkrpYovzSa4KPMUAr-zROhUlSImdPcvYkZ09y9pSA-gJAWjVaCDIaC85AY0OaLhtv_0N_AWwpcl8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Lymphocyte Muscarinic Cholinergic Activity and PGE2Involvement in ExperimentalTrypanosoma cruziInfection</title><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Sterin-Borda, Leonor ; Gorelik, Gabriela ; Goren, Nora ; Cappa, Stella Gonzalez ; Celentano, Ana M. ; Borda, Enri</creator><creatorcontrib>Sterin-Borda, Leonor ; Gorelik, Gabriela ; Goren, Nora ; Cappa, Stella Gonzalez ; Celentano, Ana M. ; Borda, Enri</creatorcontrib><description>In this paper, we demonstrated that the production of PGE2by CD8+T lymphocytes through muscarinic cholinergic receptor (mAChR) activation of lymphocytes from mice acutely infected with nonlethalTrypanosoma cruziCA-1 strain could enhance resistance to infection. Treatmentin vivowith either atropine or cyclooxygenase inhibitors enhanced mortality rates and parasitemia of mice infected withT. cruziCA-1 strain. The mechanism by which CD8+T lymphocytes released PGE2appears to involve the activation of the cells by circulating IgG present in mice infected withT. cruziCA-1 strain. Binding of these antibodies to mAChR on CD8+T lymphocytes triggered the release of large amounts of PGE2. The results point to a role of serum antibodies against mAChR in the protection ofT. cruziinfection. The prostanoid acting as an immunomodulator contributed to the maintenance of the chronic course of experimental Chagas disease.</description><identifier>ISSN: 0090-1229</identifier><identifier>EISSN: 1090-2341</identifier><identifier>DOI: 10.1006/clin.1996.0167</identifier><language>eng</language><publisher>Elsevier Inc</publisher><ispartof>Clinical immunology and immunopathology, 1996-11, Vol.81 (2), p.122-128</ispartof><rights>1996 Academic Press</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1337-999dcc66e9def814220bb2170ce2b7ca66a2962b64c8bbb4b06a7a8febf1d4083</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Sterin-Borda, Leonor</creatorcontrib><creatorcontrib>Gorelik, Gabriela</creatorcontrib><creatorcontrib>Goren, Nora</creatorcontrib><creatorcontrib>Cappa, Stella Gonzalez</creatorcontrib><creatorcontrib>Celentano, Ana M.</creatorcontrib><creatorcontrib>Borda, Enri</creatorcontrib><title>Lymphocyte Muscarinic Cholinergic Activity and PGE2Involvement in ExperimentalTrypanosoma cruziInfection</title><title>Clinical immunology and immunopathology</title><description>In this paper, we demonstrated that the production of PGE2by CD8+T lymphocytes through muscarinic cholinergic receptor (mAChR) activation of lymphocytes from mice acutely infected with nonlethalTrypanosoma cruziCA-1 strain could enhance resistance to infection. Treatmentin vivowith either atropine or cyclooxygenase inhibitors enhanced mortality rates and parasitemia of mice infected withT. cruziCA-1 strain. The mechanism by which CD8+T lymphocytes released PGE2appears to involve the activation of the cells by circulating IgG present in mice infected withT. cruziCA-1 strain. Binding of these antibodies to mAChR on CD8+T lymphocytes triggered the release of large amounts of PGE2. The results point to a role of serum antibodies against mAChR in the protection ofT. cruziinfection. The prostanoid acting as an immunomodulator contributed to the maintenance of the chronic course of experimental Chagas disease.</description><issn>0090-1229</issn><issn>1090-2341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNp1kLFOwzAURS0EEqWwMvsHEmwncuKxqkqpVARDmS3beaFGqR3ZaUT4ehyVlendN5yrq4PQIyU5JYQ_mc66nArBc0J5dYUWlAiSsaKk12hB5kwZE7foLsYvkoCSVAt03E-n_ujNNAB-PUejgnXW4PXRpzYInymvzGBHO0xYuQa_bzds50bfjXACN2Dr8Oa7h2DnT3WHMPXK-ehPCptw_rE710LivbtHN63qIjz83SX6eN4c1i_Z_m27W6_2maFFUWVCiMYYzkE00Na0ZIxozWhFDDBdGcW5YoIzzUtTa61LTbiqVN2CbmlTkrpYovzSa4KPMUAr-zROhUlSImdPcvYkZ09y9pSA-gJAWjVaCDIaC85AY0OaLhtv_0N_AWwpcl8</recordid><startdate>199611</startdate><enddate>199611</enddate><creator>Sterin-Borda, Leonor</creator><creator>Gorelik, Gabriela</creator><creator>Goren, Nora</creator><creator>Cappa, Stella Gonzalez</creator><creator>Celentano, Ana M.</creator><creator>Borda, Enri</creator><general>Elsevier Inc</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199611</creationdate><title>Lymphocyte Muscarinic Cholinergic Activity and PGE2Involvement in ExperimentalTrypanosoma cruziInfection</title><author>Sterin-Borda, Leonor ; Gorelik, Gabriela ; Goren, Nora ; Cappa, Stella Gonzalez ; Celentano, Ana M. ; Borda, Enri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1337-999dcc66e9def814220bb2170ce2b7ca66a2962b64c8bbb4b06a7a8febf1d4083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Sterin-Borda, Leonor</creatorcontrib><creatorcontrib>Gorelik, Gabriela</creatorcontrib><creatorcontrib>Goren, Nora</creatorcontrib><creatorcontrib>Cappa, Stella Gonzalez</creatorcontrib><creatorcontrib>Celentano, Ana M.</creatorcontrib><creatorcontrib>Borda, Enri</creatorcontrib><collection>CrossRef</collection><jtitle>Clinical immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sterin-Borda, Leonor</au><au>Gorelik, Gabriela</au><au>Goren, Nora</au><au>Cappa, Stella Gonzalez</au><au>Celentano, Ana M.</au><au>Borda, Enri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lymphocyte Muscarinic Cholinergic Activity and PGE2Involvement in ExperimentalTrypanosoma cruziInfection</atitle><jtitle>Clinical immunology and immunopathology</jtitle><date>1996-11</date><risdate>1996</risdate><volume>81</volume><issue>2</issue><spage>122</spage><epage>128</epage><pages>122-128</pages><issn>0090-1229</issn><eissn>1090-2341</eissn><abstract>In this paper, we demonstrated that the production of PGE2by CD8+T lymphocytes through muscarinic cholinergic receptor (mAChR) activation of lymphocytes from mice acutely infected with nonlethalTrypanosoma cruziCA-1 strain could enhance resistance to infection. Treatmentin vivowith either atropine or cyclooxygenase inhibitors enhanced mortality rates and parasitemia of mice infected withT. cruziCA-1 strain. The mechanism by which CD8+T lymphocytes released PGE2appears to involve the activation of the cells by circulating IgG present in mice infected withT. cruziCA-1 strain. Binding of these antibodies to mAChR on CD8+T lymphocytes triggered the release of large amounts of PGE2. The results point to a role of serum antibodies against mAChR in the protection ofT. cruziinfection. The prostanoid acting as an immunomodulator contributed to the maintenance of the chronic course of experimental Chagas disease.</abstract><pub>Elsevier Inc</pub><doi>10.1006/clin.1996.0167</doi><tpages>7</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0090-1229
ispartof Clinical immunology and immunopathology, 1996-11, Vol.81 (2), p.122-128
issn 0090-1229
1090-2341
language eng
recordid cdi_crossref_primary_10_1006_clin_1996_0167
source ScienceDirect Freedom Collection 2022-2024
title Lymphocyte Muscarinic Cholinergic Activity and PGE2Involvement in ExperimentalTrypanosoma cruziInfection
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T00%3A30%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lymphocyte%20Muscarinic%20Cholinergic%20Activity%20and%20PGE2Involvement%20in%20ExperimentalTrypanosoma%20cruziInfection&rft.jtitle=Clinical%20immunology%20and%20immunopathology&rft.au=Sterin-Borda,%20Leonor&rft.date=1996-11&rft.volume=81&rft.issue=2&rft.spage=122&rft.epage=128&rft.pages=122-128&rft.issn=0090-1229&rft.eissn=1090-2341&rft_id=info:doi/10.1006/clin.1996.0167&rft_dat=%3Celsevier_cross%3ES0090122996901671%3C/elsevier_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c1337-999dcc66e9def814220bb2170ce2b7ca66a2962b64c8bbb4b06a7a8febf1d4083%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true