T-Lymphocytes from Individuals with Filarial Inflammatory Disease Have Increased Transendothelial Migrationin Vitro

Thein vitrotransendothelial migration of circulating filarial antigen-specific T-cells was examined inWuchereria bancroftiinfection. Circulating T-cells from individuals with filaria-induced lymphatic pathology (LP) had significantly greater migration through unstimulated HUVEC monolayers than did T...

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Bibliographic Details
Published in:Clinical immunology and immunopathology 1997-03, Vol.82 (3), p.216-220
Main Authors: Plier, David Adam, Maia e Silva, Maria Carmelita, Maciel, Maria Amélia, Freedman, David O.
Format: Article
Language:English
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Summary:Thein vitrotransendothelial migration of circulating filarial antigen-specific T-cells was examined inWuchereria bancroftiinfection. Circulating T-cells from individuals with filaria-induced lymphatic pathology (LP) had significantly greater migration through unstimulated HUVEC monolayers than did T-cells from asymptomatic infected (MF) individuals (P= 0.04). In contrast to the MF individuals where no effect was seen, transendothelial migration of 48-hr filarial antigen stimulated T-cells from LP individuals was significantly (P= 0.01) greater than migration of 48-hr media-stimulated T-cells. In six of seven patients examined, inhibition of the VLA-4/VCAM-1 pathway resulted in greater than 50% inhibition of transendothelial migration of T-cells.
ISSN:0090-1229
1090-2341
DOI:10.1006/clin.1996.4317