Quantitative Analysis of Neuronal Damage Induced by Tri- ortho-cresyl Phosphate in Wistar Rats

Quantitative Analysis of Neuronal Damage Induced by Tri- ortho-cresyl Phosphate in Wistar Rats. Inui, K., Mitsumori, K., Harada, T., and Marva, K. (1993). Fundam. Appl. Toxicol. 20, 111-119. A quantitative analysis of neuronal damage was performed on the fasciculus gracilis (FG) of the cervical spin...

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Bibliographic Details
Published in:Fundamental and applied toxicology 1993, Vol.20 (1), p.111-119
Main Authors: Inui, Kousei, Mitsumori, Kunitoshi, Harada, Takanori, Maita, Keizo
Format: Article
Language:English
Subjects:
Animals
Axons - drug effects
Axons - ultrastructure
Biological and medical sciences
COMPOSE ORGANOPHOSPHORE
COMPUESTO ORGANICO DEL FOSFORO
Endoplasmic Reticulum - ultrastructure
Image Processing, Computer-Assisted
Male
Medical sciences
Microscopy, Electron
MODELE
MODELOS
NERF
Nerve Fibers - drug effects
NERVIOS
Neurons - drug effects
PATHOLOGIE
PATOLOGIA
Pesticides, fertilizers and other agrochemicals toxicology
RAT
RATA
Rats
Rats, Wistar
SISTEMA NERVIOSO
Spinal Cord - pathology
SYSTEME NERVEUX
TEJIDOS ANIMALES
TISSU ANIMAL
TOXICIDAD
TOXICITE
TOXICOLOGIA
TOXICOLOGIE
Toxicology
TOXINAS
TOXINE
TRASTORNOS DEL SISTEMA NERVIOSO
Tritolyl Phosphates - toxicity
TROUBLE DU SYSTEME NERVEUX
Wallerian Degeneration - drug effects
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Summary:Quantitative Analysis of Neuronal Damage Induced by Tri- ortho-cresyl Phosphate in Wistar Rats. Inui, K., Mitsumori, K., Harada, T., and Marva, K. (1993). Fundam. Appl. Toxicol. 20, 111-119. A quantitative analysis of neuronal damage was performed on the fasciculus gracilis (FG) of the cervical spinal cord in male Wistar rats that received orally a single dose of tri- ortho-cresyl phosphate (TOCP) at 1500 mg/kg. FG tissues were sampled at 1, 2, and 3 weeks after treatment and examined histopathologically. Wallerian degeneration of myelinated nerve fibers was observed in FG at 2 weeks. Morphological changes were most evident at 3 weeks after treatment and the number of fibers was reduced. Ultrastructurally, axonal swelling due to the accumulation of cytoplasmic contents was observed near the node of Ranvier in the affected animals, indicating paranodal degeneration. Axonal atrophy and swelling in organophosphorus-induced delayed neuropathy (OPIDN) were evaluated quantitatively using a computer-assisted image analyzer. Morphometric examinations on semi-thin sections and frozen sections stained with Nauta's method were demonstrated to be useful for objective evaluation of OPIDN in the rat.
ISSN:0272-0590
1095-6832
DOI:10.1006/faat.1993.1013