Chromosomal Mapping of Five Highly Conserved Murine Homologues of theDrosophilaRING Finger GeneSeven-in-absentia

Seven-in-absentia (sina)is epistatic to all other known genes in the sevenless–ras signaling pathway, which mediates R7 photoreceptor formation in theDrosophilaeye. The murine genome contains several closely relatedsinahomologues (Siah1A–D, Siah2) that are also likely to participate in ras signaling...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 1997-04, Vol.41 (2), p.160-168
Main Authors: Holloway, Andrew J., Della, Neil G., Fletcher, Colin F., Largespada, David A., Copeland, Neal G., Jenkins, Nancy A., Bowtell, David D.L.
Format: Article
Language:English
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Summary:Seven-in-absentia (sina)is epistatic to all other known genes in the sevenless–ras signaling pathway, which mediates R7 photoreceptor formation in theDrosophilaeye. The murine genome contains several closely relatedsinahomologues (Siah1A–D, Siah2) that are also likely to participate in ras signaling. As part of a genetic and biochemical analysis of the mammalianSiahgenes, we have used gene-specific probes to map the chromosomal positions of each family member. Here we report their chromosomal positions in relation to a number of known mouse mutations and also describe an analysis of the humanSiahgenes. By comparing the complexity of theSiahgenes in these two mammalian species we have gained further insight into which members of this murine multigene family are likely to be functional.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1997.4642