Significance of “Normal” Endometrial Cells in Cervical Cytology from Asymptomatic Postmenopausal Women Receiving Hormone Replacement Therapy

Objective. The aim of this study is to assess the significance of normal endometrial cells identified in screening Pap smears from asymptomatic postmenopausal women taking hormone replacement therapy (HRT). Methods. Endometrial histology reported from 93 asymptomatic postmenopausal women receiving H...

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Bibliographic Details
Published in:Gynecologic oncology 2001-04, Vol.81 (1), p.33-39
Main Author: Montz, F.J.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
cervical cytology
Cervix Uteri - cytology
endometrial cells
Endometrial Neoplasms - pathology
Endometrium - cytology
Endometrium - pathology
Estrogen Replacement Therapy - adverse effects
Estrogens - adverse effects
Female
Genital system. Mammary gland
Humans
Hyperplasia - pathology
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Middle Aged
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Polyps - pathology
Postmenopause
Precancerous Conditions - pathology
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Summary:Objective. The aim of this study is to assess the significance of normal endometrial cells identified in screening Pap smears from asymptomatic postmenopausal women taking hormone replacement therapy (HRT). Methods. Endometrial histology reported from 93 asymptomatic postmenopausal women receiving HRT noted to have normal endometrial cells on a screening Pap smear was reviewed. Information regarding HRT, endometrial sampling, and interval between the sentinel Pap and sampling was extracted from the record. Results. Endometrial biopsies were obtained an average of 1.7 months after the Pap smears. Eighteen of the ninety-three histology specimens (19%, 95% CI: 12–27%) identified abnormalities, in four cases precancerous or cancerous lesions. These 18 abnormalities included 7 endometrial polyps; 7 cases of simple hyperplasia, 1 with atypia; 3 cases of complex hyperplasia, 1 with atypia; and 1 endometrial adenocarcinoma. Conclusion. Normal endometrial cells identified on a screening Pap smear in this population may be an indication of endometrial disease.
ISSN:0090-8258
1095-6859
DOI:10.1006/gyno.2000.6106