Extractability of the Phospholipid Envelope of Magnetoliposomes by Organic Solvents

Magnetoliposomes, consisting of nanometer-sized superparamagnetic magnetite cores surrounded by a phospholipid bilayer, were subjected to extraction using various organic solvent systems. When chloroform orn-hexane were used, there was little change in the phospholipid/Fe3O4ratio. In contrast, upon...

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Bibliographic Details
Published in:Journal of colloid and interface science 1996-09, Vol.182 (2), p.478-482
Main Authors: De Cuyper, Marcel, Noppe, Wim
Format: Article
Language:English
Subjects:
Chemistry
Colloidal state and disperse state
Exact sciences and technology
General and physical chemistry
magnetoliposomes
magnetophoresis (high-gradient)
Membranes
organic solvent extraction
phospholipid vesicles
phospholipids
phospholipid–solid support interactions
water-immiscible organic solvent systems
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Summary:Magnetoliposomes, consisting of nanometer-sized superparamagnetic magnetite cores surrounded by a phospholipid bilayer, were subjected to extraction using various organic solvent systems. When chloroform orn-hexane were used, there was little change in the phospholipid/Fe3O4ratio. In contrast, upon including short-chain alcohols to these extraction systems, the outer shell of the bilayer, comprising approximately two-thirds of the original phospholipid content, was entirely removed. The resistance to extraction of the inner leaflet is due to very strong forces, thought to be chemisorptive in nature. Preliminary experiments demonstrating the apolar character of the surface of the remaining monolayer are also presented.
ISSN:0021-9797
1095-7103
DOI:10.1006/jcis.1996.0491