Spindle Bodies of Heliothis armigera Entomopoxvirus Develop in Structures Associated with Host Cell Endoplasmic Reticulum

Immunoelectron microscopy has shown that morphogenesis of spindle bodies (SB) of Heliothis armigera entomopoxvirus involves an iterative process of condensation, aggregation, and crystallization of the major constituent protein (fusolin) within the perinuclear space and endoplasmic reticulum (ER) of...

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Bibliographic Details
Published in:Journal of invertebrate pathology 2000-04, Vol.75 (3), p.183-192
Main Authors: Lai-Fook, Joan, Dall, David J.
Format: Article
Language:English
Subjects:
Animals
Antibody Specificity
Biological and medical sciences
BiP
Blotting, Western - methods
endoplasmic reticulum
Endoplasmic Reticulum - metabolism
Endoplasmic Reticulum - ultrastructure
Endoplasmic Reticulum - virology
Entomopoxvirinae - metabolism
Entomopoxvirinae - ultrastructure
Fundamental and applied biological sciences. Psychology
fusolin
insect virus
Microbiology
Morphogenesis
Moths - virology
poxvirus
Rabbits
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
spindle bodies
Viral Proteins - immunology
Viral Proteins - metabolism
Virology
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Summary:Immunoelectron microscopy has shown that morphogenesis of spindle bodies (SB) of Heliothis armigera entomopoxvirus involves an iterative process of condensation, aggregation, and crystallization of the major constituent protein (fusolin) within the perinuclear space and endoplasmic reticulum (ER) of infected cells and in vesicles derived from ER constituents. The ER-specific chaperone BiP has been observed to be associated with developing SBs at all stages of this process, and it is postulated that its sequestration within these bodies may have consequences for host cell metabolism.
ISSN:0022-2011
1096-0805
DOI:10.1006/jipa.1999.4905