ATP-sensitive K+Channels Mediate the Delayed Cardioprotective Effect of Adenosine A1Receptor Activation

Adenosine A1receptor stimulation increases myocardial resilence to ischaemia many hours later but the mechanism of protection is unclear. We hypothesized that A1receptor-induced delayed cardioprotection is mediated by KATPchannel opening. Rabbits were pretreated with saline or the selective A1recept...

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Bibliographic Details
Published in:Journal of molecular and cellular cardiology 1999-05, Vol.31 (5), p.981-989
Main Authors: Baxter, G.F., Yellon, D.M.
Format: Article
Language:English
Subjects:
2-chloro-N6-cyclopentyladenosine (CCPA)
5-hydroxydecanoate
Adenosine A1receptor
ATP-sensitive K+channel (KATP)
Glibenclamide
Infarct size
Ischaemia-reperfusion
Myocardial infarction
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Summary:Adenosine A1receptor stimulation increases myocardial resilence to ischaemia many hours later but the mechanism of protection is unclear. We hypothesized that A1receptor-induced delayed cardioprotection is mediated by KATPchannel opening. Rabbits were pretreated with saline or the selective A1receptor agonist 2-chloro-N6-cyclopentyladenosine (CCPA), 0.1 mg/kg i.v. After 24 h, they were anaesthetized and subjected to 30 min left coronary artery occlusion (CAO) and 120 min reperfusion. Twenty minutes before CAO, either glibenclamide 0.3 mg/kg, sodium 5-hydroxydecanoate (5-HD) 5 mg/kg, or a corresponding volume of vehicle solution were given i.v. Infarct size as a percentage of ischaemic risk volume (I/R%) was assessed by triphenyltetrazolium. In the absence of either glibenclamide or 5-HD, CCPA pretreatment resulted in significant limitation of infarction (I/R 23.4±3.3%vs39.6±2.6% in saline pretreated animals,P
ISSN:0022-2828
1095-8584
DOI:10.1006/jmcc.1999.0927