Coupling Topology Dependence of Polarization-Transfer Efficiency in TOCSY and TACSY Experiments

• Published in: Journal of magnetic resonance. Series A 1993-10, Vol.104 (3), p.283-301
• Main Author: Glaser, S.J.
• Format: Article
• Language: English
• Subjects: Atomic, molecular and charged-particle sources and detectors; Exact sciences and technology; Infrared, submillimeter wave, microwave and radiowave instruments, equipment and techniques; Instruments, apparatus, components and techniques common to several branches of physics and astronomy; Physics; Submillimeter wave, microwave and radiowave spectrometers; magnetic resonance spectrometers, auxiliary equipments and techniques
• ISSN: 1064-1858; 1096-0864
• DOI: 10.1006/jmra.1993.1225

The efficiency of selective and nonselective cross polarization in homo- and heteronuclear liquid-state nuclear magnetic resonance spectroscopy is investigated. A general classification scheme for TOCSY (total correlation spectroscopy) and TACSY (tailored correlation spectroscopy) experiments is introduced based on characteristic effective zero-quantum coupling tensors. The efficiency of polarization transfer with respect to transfer amplitude and transfer time is quantified and presented in the form of maps as a function of the relative coupling constants in systems consisting of three coupled spins. Characteristic differences in the polarization-transfer efficiency of TOCSY and TACSY variants are revealed and analyzed. Significant implications of these results are discussed for spin systems of practical interest.