Determination of Isomeric Nitriles with High-Performance Liquid Chromatography after Separation by Derivatization

A method is proposed for the separation of nitriles from other functional groups by derivatization. The resultingO-carboxamide amidoxime derivative of the nitrile is then identified by the use of HPLC retention times. The method has been successfully applied to isomeric monocyanopyridine and cyanoto...

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Bibliographic Details
Published in:Microchemical journal 1997-11, Vol.57 (3), p.346-349
Main Authors: Pearse, George A., Bovenzi, Brad A.
Format: Article
Language:English
Subjects:
Analytical chemistry
Chemistry
Chromatographic methods and physical methods associated with chromatography
Exact sciences and technology
Other chromatographic methods
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Summary:A method is proposed for the separation of nitriles from other functional groups by derivatization. The resultingO-carboxamide amidoxime derivative of the nitrile is then identified by the use of HPLC retention times. The method has been successfully applied to isomeric monocyanopyridine and cyanotoluenes at a 1 mg/ml limit of detection.
ISSN:0026-265X
1095-9149
DOI:10.1006/mchj.1996.1473