Complement resistance of capsulated strains ofAeromonas salmonicida

The complement resistance ofAeromonas salmonicidastrains grown under conditions promoting capsule formation was investigated using well characterized strains and their isogenic mutants. Complement resistance was previously studied using the same strains growing under noncapsulating conditions. The s...

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Bibliographic Details
Published in:Microbial pathogenesis 1997-05, Vol.22 (5), p.315-320
Main Authors: Merino, Susana, Aguilar, Alicia, Tomás, Juan M., Bonet, Ramón, Martinez, Maria Jose, Simón-Pujol, Dolores, Congregado, Francisco
Format: Article
Language:English
Subjects:
Aeromonas salmonicida
capsule
complement-mediated killing
surface molecules
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Summary:The complement resistance ofAeromonas salmonicidastrains grown under conditions promoting capsule formation was investigated using well characterized strains and their isogenic mutants. Complement resistance was previously studied using the same strains growing under noncapsulating conditions. The serum resistant strains were found to activate complement, but rapidly degrade C3b preventing productive formation of the lytic complex C5b-9. Isogenic lipopolysaccharide rough mutants grown under non-capsulating conditions were serum sensitive, binding a large amount of C3b and leading to productive formation of C5b-9. When grown under conditions promoting capsule formation, these mutants were partially resistant to complement because less C3b is bound to them and also partially degraded, with a concomitant reduction in lytic C5b-9.
ISSN:0882-4010
1096-1208
DOI:10.1006/mpat.1996.0121