Selective Immunolesion of the Basal Forebrain Cholinergic Neurons: Effects on Hippocampal Activity During Sleep and Wakefulness in the Rat

Intracerebroventricular injection of the toxin 192 IgG-saporin (4μg) kills the cholinergic neurons of the basal forebrain bearing the low affinity NGF receptor (NGFr). The effect of this cholinergic denervation on the hippocampal and cortical electrical activity (EEG) was studied during sleep and wa...

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Published in:Neurodegeneration (London, England) England), 1995-03, Vol.4 (1), p.61-70
Main Authors: Bassant, Marie H., Apartis, Emmanuelle, Jazat-Poindessous, Frédérique R., Wiley, Ronald G., Lamour, Yvon A.
Format: Article
Language:English
Subjects:
192 IgG-saporin
acetylcholine
Acetylcholine - physiology
Animals
Antibodies, Monoclonal
Cholinergic Agents
Denervation
hippocampus
Hippocampus - physiology
Histocytochemistry
Immunotoxins
Injections, Intraventricular
Male
medial septum
N-Glycosyl Hydrolases
Neurons - drug effects
Prosencephalon - cytology
Prosencephalon - drug effects
Rats
Rats, Sprague-Dawley
REM sleep
Ribosome Inactivating Proteins, Type 1
Sleep - physiology
Theta Rhythm
Wakefulness - physiology
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cited_by cdi_FETCH-LOGICAL-c339t-c84e2f623e1a8765324d50a55f82af9002335c52e5d4a5cb2a6ee64c0e62ac6a3
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container_end_page 70
container_issue 1
container_start_page 61
container_title Neurodegeneration (London, England)
container_volume 4
creator Bassant, Marie H.
Apartis, Emmanuelle
Jazat-Poindessous, Frédérique R.
Wiley, Ronald G.
Lamour, Yvon A.
Lamour, Yvon A.
description Intracerebroventricular injection of the toxin 192 IgG-saporin (4μg) kills the cholinergic neurons of the basal forebrain bearing the low affinity NGF receptor (NGFr). The effect of this cholinergic denervation on the hippocampal and cortical electrical activity (EEG) was studied during sleep and wakefulness. EEG was recorded under freely-moving conditions in lesioned (n=10) and control (n=6) rats (8–16 days post-injection). In lesioned rats, active (AW) and quiet (QW) wakefulness episode durations were similar to those of controls whereas the REM sleep duration was reduced, 8 days post-lesion (P
doi_str_mv 10.1006/neur.1995.0007
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The effect of this cholinergic denervation on the hippocampal and cortical electrical activity (EEG) was studied during sleep and wakefulness. EEG was recorded under freely-moving conditions in lesioned (n=10) and control (n=6) rats (8–16 days post-injection). In lesioned rats, active (AW) and quiet (QW) wakefulness episode durations were similar to those of controls whereas the REM sleep duration was reduced, 8 days post-lesion (P&lt;0.01). Bouts of REM sleep were more numerous but shorter. The hippocampal theta activity was still present in lesioned-rats during AW (type 1 theta), QW (type 2 theta) and REM sleep. The frequency was unchanged but the amplitude of the three types of theta was significantly reduced (P&lt;0.01). Type 2 theta occurred with shorter and less regular bouts (P&lt;0.05). Abnormal slow waves (2–4 Hz) were observed during wakefulness. 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1522-9661
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subjects 192 IgG-saporin
acetylcholine
Acetylcholine - physiology
Animals
Antibodies, Monoclonal
Cholinergic Agents
Denervation
hippocampus
Hippocampus - physiology
Histocytochemistry
Immunotoxins
Injections, Intraventricular
Male
medial septum
N-Glycosyl Hydrolases
Neurons - drug effects
Prosencephalon - cytology
Prosencephalon - drug effects
Rats
Rats, Sprague-Dawley
REM sleep
Ribosome Inactivating Proteins, Type 1
Sleep - physiology
Theta Rhythm
Wakefulness - physiology
title Selective Immunolesion of the Basal Forebrain Cholinergic Neurons: Effects on Hippocampal Activity During Sleep and Wakefulness in the Rat
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