AN ASSESSMENT OF THE POTENTIAL OF PROTOPINE TO INHIBIT MICROSOMAL DRUG METABOLISING ENZYMES AND PREVENT CHEMICAL-INDUCED HEPATOTOXICITY IN RODENTS

The potential of protopine to inhibit microsomal drug metabolising enzymes (MDM E) and prevent paracetamol- and CCl4-induced hepatotoxicity was studied in rats. Paracetamol at the dose of 640 mg kg−1produced hepatic damage in rats as manifested by the rise in serum levels of aspartate transaminase (...

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Bibliographic Details
Published in:Pharmacological research 1998-09, Vol.38 (3), p.215-219
Main Authors: JANBAZ, K.H., SAEED, S.A., GILANI, A.H.
Format: Article
Language:English
Subjects:
Acetaminophen - toxicity
Alkaloids - pharmacology
Animals
Benzophenanthridines
Berberine Alkaloids
Carbon Tetrachloride - toxicity
Cytochrome P-450 Enzyme Inhibitors
Enzyme Inhibitors - pharmacology
Liver - drug effects
Male
Microsomes, Liver - enzymology
Pentobarbital - pharmacology
protopine, anti-hepatotoxic, microsomal enzyme inhibitor
Rats
Rats, Wistar
Sleep - drug effects
Strychnine - toxicity
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Summary:The potential of protopine to inhibit microsomal drug metabolising enzymes (MDM E) and prevent paracetamol- and CCl4-induced hepatotoxicity was studied in rats. Paracetamol at the dose of 640 mg kg−1produced hepatic damage in rats as manifested by the rise in serum levels of aspartate transaminase (AST) and alanine transaminase (ALT) to 972±186 and 624±131 IU (mean±sem;n=10), respectively, compared to respective control values of 101±29 and 64±18 IU. Pretreatment of rats with protopine (11 mg kg−1, orally twice daily for 2 days) lowered significantly the respective serum AST and ALT levels (P
ISSN:1043-6618
1096-1186
DOI:10.1006/phrs.1998.0353