Brain lesions following combined treatment with methotrexate and craniospinal irradiation

Eight patients with meningeal seeding by carcinoma or lymphomas were treated with intravenous (i.v.) and/or intrathecal (i.th.) Methotrexate (MTX). Seven patients received additional craniospinal irradiation and in all seven a fatal encephalopathy developed. On the bases of clinical and morphologica...

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Bibliographic Details
Published in:Journal of neuro-oncology 1991-04, Vol.10 (2), p.165-171
Main Authors: CRUZ-SANCHEZ, F. F, ARTIGAS, J, CERVOS-NAVARRO, J, ROSSI, M. L, FERSZT, R
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Brain Diseases - chemically induced
Brain Diseases - diagnosis
Brain Diseases - etiology
Brain Edema - chemically induced
Breast Neoplasms - drug therapy
Breast Neoplasms - therapy
Child, Preschool
Combined Modality Therapy
Cranial Irradiation - adverse effects
Demyelinating Diseases
Diagnosis, Differential
Diseases of the nervous system
Female
Gastrointestinal Diseases - chemically induced
Humans
Injections, Intravenous
Injections, Spinal
Lymphoma - drug therapy
Lymphoma - therapy
Male
Medical sciences
Meningeal Neoplasms - drug therapy
Meningeal Neoplasms - radiotherapy
Meningeal Neoplasms - secondary
Mental Disorders - diagnosis
Methotrexate - administration & dosage
Methotrexate - adverse effects
Methotrexate - therapeutic use
Middle Aged
Necrosis
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
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Summary:Eight patients with meningeal seeding by carcinoma or lymphomas were treated with intravenous (i.v.) and/or intrathecal (i.th.) Methotrexate (MTX). Seven patients received additional craniospinal irradiation and in all seven a fatal encephalopathy developed. On the bases of clinical and morphological findings we identified an acute and a delayed form of encephalopathy and concluded that the concurrent administration of Methotrexate and of craniospinal irradiation increases considerably the risk of brain damage.
ISSN:0167-594X
1573-7373
DOI:10.1007/BF00146878