Facilitated transport of glucose from blood to brain in man and the effect of moderate hypoglycaemia on cerebral glucose utilization

The effect of steady-state moderate hypoglycaemia on human brain homeostasis has been studied with positron emission tomography using [U-11C]-D-glucose as tracer. To rule out any effects of insulin, the plasma insulin concentration was maintained at the same level under normo- and hypoglycaemic cond...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 1991-10, Vol.18 (10), p.834-837
Main Authors: BLOMQVIST, G, GJEDDE, A, GUTNIAK, M, GRILL, V, WIDEN, L, STONE-ELANDER, S, HELLSTRAND, E
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biological Transport
Blood-Brain Barrier - physiology
Brain - metabolism
Glucose - pharmacokinetics
Humans
Hypoglycemia - physiopathology
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Nervous system
Radionuclide investigations
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Summary:The effect of steady-state moderate hypoglycaemia on human brain homeostasis has been studied with positron emission tomography using [U-11C]-D-glucose as tracer. To rule out any effects of insulin, the plasma insulin concentration was maintained at the same level under normo- and hypoglycaemic conditions. Reduction of blood glucose by 55% increased the glucose clearance through the blood-brain barrier by 50% and reduced brain glucose consumption by 40%. Blood flow was not affected. The results are consistent with facilitated transport of glucose from blood to brain in humans. The maximal transport rate of glucose from blood to brain was found to be 62 +/- 19 (mean +/- SEM) mumol hg-1 min-1, and the half-saturation constant was found to be 4.1 +/- 2.3 mM.
ISSN:0340-6997
1619-7089
DOI:10.1007/BF00175064