Evaluation of the renal excretion characteristics of technetium-99m mercaptoacetylglycyl-D-alanylglycine in healthy volunteers

During a study of C-methyl derivatives of technetium-99m mercaptoacetyltriglycine (99mTc-MAG3) it was found that the isomer of 99mTc-mercaptoacetylglycyl-D-alanylglycine (99m-TC-MAGAG-DA) is superior to 99mTc-MAG3 with regard to its renal excretion characteristics in both mice and the baboon. We hav...

Full description

Saved in:
Bibliographic Details
Published in:European Journal of Nuclear Medicine 1992-04, Vol.19 (4), p.271-277
Main Authors: BORMANS, G. M, CLEYNHEN, B. J, E ROO, M. J. K, VERBRUGGEN, A. M
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Humans
Kidney - metabolism
Male
Oligopeptides - blood
Oligopeptides - metabolism
Oligopeptides - urine
Organotechnetium Compounds - blood
Organotechnetium Compounds - metabolism
Organotechnetium Compounds - urine
Radioisotope Renography
Technetium Tc 99m Mertiatide
Vertebrates: urinary system
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:During a study of C-methyl derivatives of technetium-99m mercaptoacetyltriglycine (99mTc-MAG3) it was found that the isomer of 99mTc-mercaptoacetylglycyl-D-alanylglycine (99m-TC-MAGAG-DA) is superior to 99mTc-MAG3 with regard to its renal excretion characteristics in both mice and the baboon. We have now compared the renal handling of 99mTc-MAGAG-DA and 99mTc-MAG3 in 6 healthy volunteers in a paired study. Renograms of 99mTc-MAGAG-DA show a shorter time to renal maximum and a lower residual renal activity at 30 min post-injection (p.i.). The urinary excretion of 99mTc-MAGAG-DA is higher at both 30 and 60 min p.i. The plasma concentration of 99mTc-MAGAG-DA is lower than that of 99mTc-MAG3 at each moment up to 60 min p.i., and the plasma clearance is accordingly higher. It is concluded that 99mTc-MAGAG-DA is excreted more efficiently than 99mTc-MAG3, but the preparation of 99mTc-MAGAG-DA requires a HPLC purification step, and this limits its practical clinical usefulness.
ISSN:0340-6997
1619-7089
DOI:10.1007/BF00175141