Phase II study of 5-fluorouracil and leucovorin in recurrent primary brain tumor

Thirty patients with recurrent primary brain tumors were treated with a combination of 5-fluorouracil and leucovorin. There were three responses seen. Toxicity consisted of stomatitis, diarrhea, and hematological suppression. 5-fluorouracil and leucovorin would appear to be minimally effective in re...

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Bibliographic Details
Published in:Journal of neuro-oncology 1996-12, Vol.30 (3), p.243-246
Main Authors: CASCINO, T. L, VEEDER, M. H, BUCKNER, J. C, O'FALLON, J. R, WIESENFELD, M, LEVITT, R, GOLDBERG, R. M, KUROSS, S. A, MORTON, R. F, SCHEITHAUER, B. W
Format: Article
Language:English
Subjects:
Adult
Aged
Antidotes - therapeutic use
Antidotes - toxicity
Antimetabolites, Antineoplastic - therapeutic use
Antimetabolites, Antineoplastic - toxicity
Antineoplastic agents
Astrocytoma - drug therapy
Biological and medical sciences
Brain Neoplasms - drug therapy
Chemotherapy
Female
Fluorouracil - therapeutic use
Fluorouracil - toxicity
Humans
Leucovorin - therapeutic use
Leucovorin - toxicity
Leukopenia - chemically induced
Male
Medical sciences
Middle Aged
Oligodendroglioma - drug therapy
Pharmacology. Drug treatments
Recurrence
Stomatitis - chemically induced
Thrombocytopenia - chemically induced
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Description
Summary:Thirty patients with recurrent primary brain tumors were treated with a combination of 5-fluorouracil and leucovorin. There were three responses seen. Toxicity consisted of stomatitis, diarrhea, and hematological suppression. 5-fluorouracil and leucovorin would appear to be minimally effective in recurrent brain tumors.
ISSN:0167-594X
1573-7373
DOI:10.1007/BF00177275