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Acute morphine dependence: effects observed in shock and light discrimination tasks
Alterations in shock discrimination accuracy in the rat, indicative of hyperalgesia, have been noted 1-3 days following a single injection of morphine. To establish the extent to which these "withdrawal-like" effects were specific to the shock discrimination paradigm, rats were trained in...
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Published in: | Psychopharmacologia 1986-01, Vol.88 (4), p.500-504 |
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description | Alterations in shock discrimination accuracy in the rat, indicative of hyperalgesia, have been noted 1-3 days following a single injection of morphine. To establish the extent to which these "withdrawal-like" effects were specific to the shock discrimination paradigm, rats were trained in two separate discrimination tasks. The discriminative stimuli (SD,s) for correct lever presses were mild electric shocks of different intensities in one task and were short duration lights over the levers in the other. After achieving comparable accuracy levels in the two tasks, the animals were injected SC with 30 mg/kg morphine sulfate and performance levels assessed 1, 2, 3, and 7 days later. Shock discrimination accuracy was significantly enhanced on post-morphine day 2, while accuracy in the light position task was not significantly affected on any of the post-morphine test days. The results indicated that increased pain sensitivity, as well as other signs of dependence, can occur following acute exposure to morphine. |
doi_str_mv | 10.1007/BF00178515 |
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The results indicated that increased pain sensitivity, as well as other signs of dependence, can occur following acute exposure to morphine.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/BF00178515</identifier><identifier>PMID: 3085139</identifier><identifier>CODEN: PSYPAG</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Applied sciences ; Biological and medical sciences ; Conditioning, Operant - physiology ; Discrimination (Psychology) - physiology ; Drug addictions ; Electroshock ; Exact sciences and technology ; Male ; Medical sciences ; Morphine Dependence - physiopathology ; Motivation - physiology ; Naloxone ; Other techniques and industries ; Pain - physiopathology ; Rats ; Rats, Inbred Strains ; Substance Withdrawal Syndrome - physiopathology ; Toxicology</subject><ispartof>Psychopharmacologia, 1986-01, Vol.88 (4), p.500-504</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-1ad2a6be2a2099341e090675669294b155d85a389143f0e0ce3ecdeba1a539063</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8101567$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8106015$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3085139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GRILLY, D. 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Shock discrimination accuracy was significantly enhanced on post-morphine day 2, while accuracy in the light position task was not significantly affected on any of the post-morphine test days. The results indicated that increased pain sensitivity, as well as other signs of dependence, can occur following acute exposure to morphine.</description><subject>Animals</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Conditioning, Operant - physiology</subject><subject>Discrimination (Psychology) - physiology</subject><subject>Drug addictions</subject><subject>Electroshock</subject><subject>Exact sciences and technology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Morphine Dependence - physiopathology</subject><subject>Motivation - physiology</subject><subject>Naloxone</subject><subject>Other techniques and industries</subject><subject>Pain - physiopathology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Substance Withdrawal Syndrome - physiopathology</subject><subject>Toxicology</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><recordid>eNqFkD1PwzAQhi0EKqWwsCN5YEIKnO04H2ylooBUiQGYI8e-UNPWiewUiX-PoVEZueWG99Gru4eQcwbXDCC_uZsDsLyQTB6QMUsFTzjk_JCMAYRIBJPFMTkJ4QPipEU6IiMBkRblmLxM9bZHuml9t7QOqcEOnUGn8ZZi06DuA23rgP4TDbWOhmWrV1Q5Q9f2fdlTY4P2dmOd6m3raK_CKpySo0atA54Ne0Le5vevs8dk8fzwNJsuEi1S6BOmDFdZjVxxKEuRMoQSslxmWcnLtGZSmkIqUZTxowYQNArUBmvFlBSRFBNytevVvg3BY1N18RTlvyoG1Y-Y6k9MhC92cLetN2j26GAi5pdDroJW68Yrp23YYwWDDH5r_sOYzHLxDXqtdhs</recordid><startdate>19860101</startdate><enddate>19860101</enddate><creator>GRILLY, D. 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C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute morphine dependence: effects observed in shock and light discrimination tasks</atitle><jtitle>Psychopharmacologia</jtitle><addtitle>Psychopharmacology (Berl)</addtitle><date>1986-01-01</date><risdate>1986</risdate><volume>88</volume><issue>4</issue><spage>500</spage><epage>504</epage><pages>500-504</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><coden>PSYPAG</coden><abstract>Alterations in shock discrimination accuracy in the rat, indicative of hyperalgesia, have been noted 1-3 days following a single injection of morphine. To establish the extent to which these "withdrawal-like" effects were specific to the shock discrimination paradigm, rats were trained in two separate discrimination tasks. The discriminative stimuli (SD,s) for correct lever presses were mild electric shocks of different intensities in one task and were short duration lights over the levers in the other. After achieving comparable accuracy levels in the two tasks, the animals were injected SC with 30 mg/kg morphine sulfate and performance levels assessed 1, 2, 3, and 7 days later. Shock discrimination accuracy was significantly enhanced on post-morphine day 2, while accuracy in the light position task was not significantly affected on any of the post-morphine test days. The results indicated that increased pain sensitivity, as well as other signs of dependence, can occur following acute exposure to morphine.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>3085139</pmid><doi>10.1007/BF00178515</doi><tpages>5</tpages></addata></record> |
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subjects | Animals Applied sciences Biological and medical sciences Conditioning, Operant - physiology Discrimination (Psychology) - physiology Drug addictions Electroshock Exact sciences and technology Male Medical sciences Morphine Dependence - physiopathology Motivation - physiology Naloxone Other techniques and industries Pain - physiopathology Rats Rats, Inbred Strains Substance Withdrawal Syndrome - physiopathology Toxicology |
title | Acute morphine dependence: effects observed in shock and light discrimination tasks |
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