Interaction between chronic amphetamine and neuroleptic treatments on oral behavior in rats

• Published in: Psychopharmacologia 1987-01, Vol.93 (2), p.218-222
• Main Authors: LEVY, A. D, ELLISON, G. D
• Format: Article
• Language: English
• Subjects: Amphetamine - administration & dosage; Amphetamine - toxicity; Animals; Behavior, Animal - drug effects; Biological and medical sciences; Body Weight - drug effects; Drug Interactions; Dyskinesia, Drug-Induced - etiology; Female; Haloperidol - administration & dosage; Haloperidol - toxicity; Medical sciences; Motor Activity - drug effects; Mouth; Neuropharmacology; Pharmacology. Drug treatments; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Rats; Rats, Inbred Strains; Receptors, Dopamine - drug effects; Receptors, Dopamine - physiology
• ISSN: 0033-3158; 1432-2072
• DOI: 10.1007/BF00179937

The interaction of concurrently administered amphetamine (AMPH) and haloperidol (HAL) on behavior was examined. Rats were divided into four groups: drug naive controls; HAL-treated for 6 months; AMPH-treated for 1 month; and rats administered both continuous HAL for 6 months and concurrent AMPH treatment during the 2nd month of HAL administration. AMPH alone increased locomotor activity, and this effect was blocked by concurrent haloperidol administration; however, the AMPH-induced reduction of body weight was unaltered by concurrent haloperidol treatment. Oral behavior, monitored both by a human observer and a computerized system, was not significantly altered by HAL alone, or by AMPH alone, but increases in tremorous oral behavior appeared in the concurrent administration group 4 months after AMPH treatment was discontinued. These results could have implications for tardive dyskinesia.