Radioimmunoimaging of subacute infective endocarditis using a technetium-99m monoclonal granulocyte-specific antibody

Immunoscintigraphy with a technetium-99m murine monoclonal IgG1 antibody directed against non-specific cross-reacting antigen (NCA-95) and carcinoembryonic antigen was performed with 20 patients with suspected subacute infective endocarditis (SIE) and 6 controls with suspected inflammatory/infectiou...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 1991-12, Vol.18 (12), p.977-980
Main Authors: MUNZ, D. L, MORGUET, A. J, SANDROCK, D, HEIM, A, SOLD, G, FIGULLA, H. R, KREUZER, H, EMRICH, D
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Child
Endocarditis, Subacute Bacterial - diagnostic imaging
Endocarditis, Subacute Bacterial - epidemiology
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Prospective Studies
Radioimmunodetection - methods
Technetium
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Summary:Immunoscintigraphy with a technetium-99m murine monoclonal IgG1 antibody directed against non-specific cross-reacting antigen (NCA-95) and carcinoembryonic antigen was performed with 20 patients with suspected subacute infective endocarditis (SIE) and 6 controls with suspected inflammatory/infectious disease elsewhere in the body. Immunoscintigraphy and echocardiography localised SIE in 11 of 15 patients in whom the disease could be confirmed. In 4 patients with validated SIE, the immunoscan was abnormal, and the echocardiogram was normal. In another 4 patients, the result was exactly the opposite. These findings suggest that the combination of immunoscintigraphy and echocardiography improves diagnostic efficacy in patients with suspected SIE.
ISSN:0340-6997
1619-7089
DOI:10.1007/BF00180419