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Radioimmunoimaging of subacute infective endocarditis using a technetium-99m monoclonal granulocyte-specific antibody
Immunoscintigraphy with a technetium-99m murine monoclonal IgG1 antibody directed against non-specific cross-reacting antigen (NCA-95) and carcinoembryonic antigen was performed with 20 patients with suspected subacute infective endocarditis (SIE) and 6 controls with suspected inflammatory/infectiou...
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| Published in: | European Journal of Nuclear Medicine 1991-12, Vol.18 (12), p.977-980 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 980 |
| container_issue | 12 |
| container_start_page | 977 |
| container_title | European Journal of Nuclear Medicine |
| container_volume | 18 |
| creator | MUNZ, D. L MORGUET, A. J SANDROCK, D HEIM, A SOLD, G FIGULLA, H. R KREUZER, H EMRICH, D |
| description | Immunoscintigraphy with a technetium-99m murine monoclonal IgG1 antibody directed against non-specific cross-reacting antigen (NCA-95) and carcinoembryonic antigen was performed with 20 patients with suspected subacute infective endocarditis (SIE) and 6 controls with suspected inflammatory/infectious disease elsewhere in the body. Immunoscintigraphy and echocardiography localised SIE in 11 of 15 patients in whom the disease could be confirmed. In 4 patients with validated SIE, the immunoscan was abnormal, and the echocardiogram was normal. In another 4 patients, the result was exactly the opposite. These findings suggest that the combination of immunoscintigraphy and echocardiography improves diagnostic efficacy in patients with suspected SIE. |
| doi_str_mv | 10.1007/BF00180419 |
| format | article |
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L ; MORGUET, A. J ; SANDROCK, D ; HEIM, A ; SOLD, G ; FIGULLA, H. R ; KREUZER, H ; EMRICH, D</creator><creatorcontrib>MUNZ, D. L ; MORGUET, A. J ; SANDROCK, D ; HEIM, A ; SOLD, G ; FIGULLA, H. R ; KREUZER, H ; EMRICH, D</creatorcontrib><description>Immunoscintigraphy with a technetium-99m murine monoclonal IgG1 antibody directed against non-specific cross-reacting antigen (NCA-95) and carcinoembryonic antigen was performed with 20 patients with suspected subacute infective endocarditis (SIE) and 6 controls with suspected inflammatory/infectious disease elsewhere in the body. Immunoscintigraphy and echocardiography localised SIE in 11 of 15 patients in whom the disease could be confirmed. In 4 patients with validated SIE, the immunoscan was abnormal, and the echocardiogram was normal. In another 4 patients, the result was exactly the opposite. These findings suggest that the combination of immunoscintigraphy and echocardiography improves diagnostic efficacy in patients with suspected SIE.</description><identifier>ISSN: 0340-6997</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/BF00180419</identifier><identifier>PMID: 1778210</identifier><identifier>CODEN: EJNMD9</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Child ; Endocarditis, Subacute Bacterial - diagnostic imaging ; Endocarditis, Subacute Bacterial - epidemiology ; Female ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Prospective Studies ; Radioimmunodetection - methods ; Technetium</subject><ispartof>European Journal of Nuclear Medicine, 1991-12, Vol.18 (12), p.977-980</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c226t-bc3c80d41ba1cafe0a63de13ca061d48f1a66c05e33f710075c58ec4676667f73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5404787$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1778210$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MUNZ, D. L</creatorcontrib><creatorcontrib>MORGUET, A. J</creatorcontrib><creatorcontrib>SANDROCK, D</creatorcontrib><creatorcontrib>HEIM, A</creatorcontrib><creatorcontrib>SOLD, G</creatorcontrib><creatorcontrib>FIGULLA, H. R</creatorcontrib><creatorcontrib>KREUZER, H</creatorcontrib><creatorcontrib>EMRICH, D</creatorcontrib><title>Radioimmunoimaging of subacute infective endocarditis using a technetium-99m monoclonal granulocyte-specific antibody</title><title>European Journal of Nuclear Medicine</title><addtitle>Eur J Nucl Med</addtitle><description>Immunoscintigraphy with a technetium-99m murine monoclonal IgG1 antibody directed against non-specific cross-reacting antigen (NCA-95) and carcinoembryonic antigen was performed with 20 patients with suspected subacute infective endocarditis (SIE) and 6 controls with suspected inflammatory/infectious disease elsewhere in the body. Immunoscintigraphy and echocardiography localised SIE in 11 of 15 patients in whom the disease could be confirmed. In 4 patients with validated SIE, the immunoscan was abnormal, and the echocardiogram was normal. In another 4 patients, the result was exactly the opposite. These findings suggest that the combination of immunoscintigraphy and echocardiography improves diagnostic efficacy in patients with suspected SIE.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Endocarditis, Subacute Bacterial - diagnostic imaging</subject><subject>Endocarditis, Subacute Bacterial - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Radioimmunodetection - methods</subject><subject>Technetium</subject><issn>0340-6997</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><recordid>eNpFkM1r3DAQR0VpSTdJL70XdCg5BJyMVrJkH9OQLwgUSnI28ni0VbGlrSUV9r-vl12Sy8zh93iHx9hXAVcCwFz_uAcQDSjRfmAroUVbGWjaj2wFUkGl29Z8Zqcp_QEApWR9wk6EMc1awIqVX3bw0U9TCcu1Gx82PDqeSm-xZOI-OMLs_xGnMES08-CzT7ykPWh5JvwdKPsyVW078SmGiGMMduSb2YYyRtxlqtKW0DuP3Ibs-zjsztknZ8dEX47_jL3e373cPlbPPx-ebm-eK1yvda56lNjAoERvBVpHYLUcSEi0oMWgGies1gg1SenMvkSNdUOotNFaG2fkGbs4eLdz_Fso5W7yCWkcbaBYUmfWSyxo5AJeHkCcY0ozuW47LznmXSeg25u798YL_O1oLf1Ewzt6iLrs34-7TWhHt5RAn96wWoEyjZH_AbM2hZw</recordid><startdate>199112</startdate><enddate>199112</enddate><creator>MUNZ, D. 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R ; KREUZER, H ; EMRICH, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c226t-bc3c80d41ba1cafe0a63de13ca061d48f1a66c05e33f710075c58ec4676667f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Endocarditis, Subacute Bacterial - diagnostic imaging</topic><topic>Endocarditis, Subacute Bacterial - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Radioimmunodetection - methods</topic><topic>Technetium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MUNZ, D. L</creatorcontrib><creatorcontrib>MORGUET, A. J</creatorcontrib><creatorcontrib>SANDROCK, D</creatorcontrib><creatorcontrib>HEIM, A</creatorcontrib><creatorcontrib>SOLD, G</creatorcontrib><creatorcontrib>FIGULLA, H. R</creatorcontrib><creatorcontrib>KREUZER, H</creatorcontrib><creatorcontrib>EMRICH, D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European Journal of Nuclear Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MUNZ, D. L</au><au>MORGUET, A. J</au><au>SANDROCK, D</au><au>HEIM, A</au><au>SOLD, G</au><au>FIGULLA, H. R</au><au>KREUZER, H</au><au>EMRICH, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radioimmunoimaging of subacute infective endocarditis using a technetium-99m monoclonal granulocyte-specific antibody</atitle><jtitle>European Journal of Nuclear Medicine</jtitle><addtitle>Eur J Nucl Med</addtitle><date>1991-12</date><risdate>1991</risdate><volume>18</volume><issue>12</issue><spage>977</spage><epage>980</epage><pages>977-980</pages><issn>0340-6997</issn><eissn>1619-7089</eissn><coden>EJNMD9</coden><abstract>Immunoscintigraphy with a technetium-99m murine monoclonal IgG1 antibody directed against non-specific cross-reacting antigen (NCA-95) and carcinoembryonic antigen was performed with 20 patients with suspected subacute infective endocarditis (SIE) and 6 controls with suspected inflammatory/infectious disease elsewhere in the body. Immunoscintigraphy and echocardiography localised SIE in 11 of 15 patients in whom the disease could be confirmed. In 4 patients with validated SIE, the immunoscan was abnormal, and the echocardiogram was normal. In another 4 patients, the result was exactly the opposite. These findings suggest that the combination of immunoscintigraphy and echocardiography improves diagnostic efficacy in patients with suspected SIE.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>1778210</pmid><doi>10.1007/BF00180419</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-6997 |
| ispartof | European Journal of Nuclear Medicine, 1991-12, Vol.18 (12), p.977-980 |
| issn | 0340-6997 1619-7089 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00180419 |
| source | Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Child Endocarditis, Subacute Bacterial - diagnostic imaging Endocarditis, Subacute Bacterial - epidemiology Female Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Prospective Studies Radioimmunodetection - methods Technetium |
| title | Radioimmunoimaging of subacute infective endocarditis using a technetium-99m monoclonal granulocyte-specific antibody |
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