Optimizing technetium 99m diethylene triamine penta-acetate lung clearance in patients with the acquired immunodeficiency syndrome

Pneumocystis carinii pneumonia (PCP) has become a major cause of morbidity and mortality due to infectious diseases, largely as a result of the acquired immunodeficiency syndrome (AIDS) epidemic. Since the mortality from recurrent infection is between 40% and 60%, early diagnosis and therapy are the...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 1991-04, Vol.18 (4), p.235-240
Main Authors: VAN DER WALL, H, MURRAY, I. P. C, JONES, P. D, MACKEY, D. W. J, WALKER, B. M, MONAGHAN, P
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - complications
Adult
Aerosols
AIDS/HIV
Biological and medical sciences
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Lung - diagnostic imaging
Male
Medical sciences
Pneumonia, Pneumocystis - complications
Pneumonia, Pneumocystis - diagnostic imaging
Radionuclide Imaging
Radionuclide investigations
Respiratory system
Sensitivity and Specificity
Technetium Tc 99m Pentetate
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Summary:Pneumocystis carinii pneumonia (PCP) has become a major cause of morbidity and mortality due to infectious diseases, largely as a result of the acquired immunodeficiency syndrome (AIDS) epidemic. Since the mortality from recurrent infection is between 40% and 60%, early diagnosis and therapy are the keys to survival. The role of technetium 99m diethylene triamine penta-acetate (DTPA) aerosol pulmonary clearance was studied in 81 patients with AIDS. The mathematical technique of curve stripping was found to be the optimal method of analysis and to provide an overall sensitivity of 94% for the detection of interstitial pneumonitis. The procedure was superior to standard pathology parameters and radiography and more convenient than gallium 67 scintigraphy.
ISSN:0340-6997
1619-7089
DOI:10.1007/BF00186646