Comparative efficacy and tolerance of ibuprofen syrup and acetaminophen syrup in children with pyrexia associated with infectious diseases and treated with antibiotics

A double-blind, randomised, parallel group study has been done comparing the efficacy and tolerability of 7.5 mg/kg ibuprofen syrup (n = 77) and 10 mg.kg-1 acetaminophen syrup (n = 77) in 154 children (6 months to 5 years) with fever (> or = 38 degrees C) associated with infectious diseases and t...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1994-04, Vol.46 (3), p.197-201
Main Authors: AUTRET, E, BREART, G, JONVILLE, A. P, COURCIER, S, LASSALE, C, GOEHRS, J. M
Format: Article
Language:English
Subjects:
Acetaminophen - administration & dosage
Acetaminophen - adverse effects
Acetaminophen - therapeutic use
Analgesics
Anti-Bacterial Agents - therapeutic use
Biological and medical sciences
Child, Preschool
Double-Blind Method
Female
Fever - drug therapy
Fever - etiology
Humans
Ibuprofen - administration & dosage
Ibuprofen - adverse effects
Ibuprofen - therapeutic use
Infant
Infection - complications
Infection - drug therapy
Male
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Solutions
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Summary:A double-blind, randomised, parallel group study has been done comparing the efficacy and tolerability of 7.5 mg/kg ibuprofen syrup (n = 77) and 10 mg.kg-1 acetaminophen syrup (n = 77) in 154 children (6 months to 5 years) with fever (> or = 38 degrees C) associated with infectious diseases and treated with antibiotic therapy. The area under the percentage reduction in temperature curve captured the net effect of each drug and provided the best estimate for comparison of efficacy during a defined period. Temperature evolution over time was not significantly different between the two groups. Nevertheless, the temperature reduction over the first 4 h of treatment (H0-H4) was significantly higher after ibuprofen (60%) than acetaminophen (45%). Both ibuprofen and acetaminophen were well tolerated. In conclusion, significant antipyretic activity, good tolerability and its availability as a syrup make ibuprofen an effective means of fever control in children.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00192548