Biochemical changes during amlodipine treatment in hypertensive patients

Twenty adult hypertensive patients mean age (52 (1.73) y) were treated with amlodipine 5 mg (8 patients) and 10 mg (12 patients) once daily for 12 weeks. There was a reduction in sitting and standing diastolic and systolic blood pressures in male and female patients. Plasma calcium, sodium, potassiu...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1994-04, Vol.46 (3), p.249-251
Main Authors: AHANEKU, J. E, TAYLOR, G. O, WALKER, O, AGBEDANA, E. O, SOWUNMI, A, SALAKO, L. A
Format: Article
Language:English
Subjects:
African Continental Ancestry Group
Amlodipine - adverse effects
Amlodipine - therapeutic use
Antihypertensive agents
Biological and medical sciences
Blood Chemical Analysis
Blood Pressure - drug effects
Cardiovascular system
Female
Humans
Hypertension - blood
Hypertension - drug therapy
Hypertension - metabolism
Male
Medical sciences
Middle Aged
Nigeria
Pharmacology. Drug treatments
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Summary:Twenty adult hypertensive patients mean age (52 (1.73) y) were treated with amlodipine 5 mg (8 patients) and 10 mg (12 patients) once daily for 12 weeks. There was a reduction in sitting and standing diastolic and systolic blood pressures in male and female patients. Plasma calcium, sodium, potassium, total proteins, albumin, globulins, phosphate, chloride, urea and haematological parameters were not significantly altered by amlodipine therapy in any patient. An increase in creatinine level was noted, which was not related to kidney dysfunction. We conclude that amlodipine 5 mg or 10 mg once daily is effective in male and female patients, and it does not alter biochemical and haematological values in hypertensive African patients.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00192557