Alpha1-antitrypsin: evidence for a fourth PiM allele. Distribution of the PiM subtypes in Southern Germany

Subtypes of the protease inhibitor (Pi) alpha 1-antitrypsin were determined in sera from 752 unrelated individuals from Southern Germany. By isoelectric focusing nine common PiM subtypes were distinguished and several rare Pi variants were observed. Family studies confirm the existence of a fourth P...

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Bibliographic Details
Published in:Zeitschrift f r Rechtsmedizin 1982, Vol.88 (3), p.203-211
Main Authors: Weidinger, S, Cleve, H, Patutschnick, W
Format: Article
Language:English
Subjects:
Adult
Alleles
alpha 1-Antitrypsin - genetics
Child
Female
Gene Frequency
Germany, West
Humans
Isoelectric Focusing
Male
Paternity
Phenotype
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Summary:Subtypes of the protease inhibitor (Pi) alpha 1-antitrypsin were determined in sera from 752 unrelated individuals from Southern Germany. By isoelectric focusing nine common PiM subtypes were distinguished and several rare Pi variants were observed. Family studies confirm the existence of a fourth PiM suballele. The frequency of PiM4 was found to be 0.018. A survey of the distribution of Pi alleles is given; the application of Pi subtyping in cases of disputed paternity is discussed.
ISSN:0044-3433
1437-1596
DOI:10.1007/BF00200725