Plasminogen (PLG): a useful genetic marker for paternity examinations

The genetically determined polymorphism of plasminogen (PLG) was analyzed by isoelectric focusing on polyacrylamide gels. For analysis neuraminidase-pretreated sera were used. PLG was developed functionally by activation with urokinase and subsequent lysis of casein in an agar overlay. In a random s...

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Bibliographic Details
Published in:Zeitschrift f r Rechtsmedizin 1985-01, Vol.94 (3), p.165-171
Main Authors: Weidinger, S, Schwarzfischer, F, Müller, H, Cleve, H
Format: Article
Language:English
Subjects:
Adult
Alleles
Child
Ethnic Groups
Female
Gene Frequency
Genetic Markers
Germany, West
Humans
Male
Paternity
Phenotype
Plasminogen - genetics
Polymorphism, Genetic
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Summary:The genetically determined polymorphism of plasminogen (PLG) was analyzed by isoelectric focusing on polyacrylamide gels. For analysis neuraminidase-pretreated sera were used. PLG was developed functionally by activation with urokinase and subsequent lysis of casein in an agar overlay. In a random sample of 957 unrelated healthy individuals from Southern Germany, three common phenotypes, PLG1, 2-1, and 2, and five rare variants were found. The allele frequencies were: PLG*1 = 0.7174, PLG*2 = 0.2780, and PLG*Var = 0.0046. The theoretical exclusion rate in cases of disputed paternity is 16.5%.
ISSN:0044-3433
1437-1596
DOI:10.1007/BF00204080