Ultrastructural alterations in skeletal muscle fibers of streptozotocin-diabetic rats

The ultrastructure of fast-twitch-oxidative-glycolytic (FOG), fast-twitch-glycolytic (FG) and slow-twitch-oxidative (SO) fibers in plantaris and soleus muscles of normal and streptozotocin-diabetic rats was studied. In the diabetic animals, the mitochondria of FOG and SO fibers showed a loss of cris...

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Bibliographic Details
Published in:Cell and tissue research 1976-05, Vol.168 (2), p.239-246
Main Authors: Chao, T T, Ianuzzo, C D, Armstrong, R B, Albright, J T, Anapolle, S E
Format: Article
Language:English
Subjects:
Animals
Diabetes Mellitus - chemically induced
Diabetes Mellitus - pathology
Glycolysis
Male
Mitochondria, Muscle - ultrastructure
Muscles - ultrastructure
Oxidation-Reduction
Rats
Streptozocin
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Summary:The ultrastructure of fast-twitch-oxidative-glycolytic (FOG), fast-twitch-glycolytic (FG) and slow-twitch-oxidative (SO) fibers in plantaris and soleus muscles of normal and streptozotocin-diabetic rats was studied. In the diabetic animals, the mitochondria of FOG and SO fibers showed a loss of cristae and an increase in electron-dense granules. There was also an increased number of lipid droplets in close proximity to the mitochondria and the nuclei, and a separation of individual muscle nuclei to form satellite cells. Higher incidences of surface projections and sarcoplasmic splittings at the nuclear region were noticed in SO fibers. The FG fibers showed some disorientation of the T-tubular system. It is concluded that streptozotocin-diabetes has differential effects on the fine structure of the three fiber types of rat skeletal muscle.
ISSN:0302-766X
1432-0878
DOI:10.1007/BF00215880