Morphometric study of the sensory neuron and peripheral nerve changes induced by chronic cisplatin (DDP) administration in rats

We performed a morphological, morphometric and toxicological study on the spinal ganglia and peripheral nerves of the rat after chronic administration of cisplatin (cis-dichlorodiammineplatinum II; DDP) with two different schedules. Severe damage of the spinal ganglia neurons was demonstrated with p...

Full description

Saved in:
Bibliographic Details
Published in:Acta neuropathologica 1992-09, Vol.84 (4), p.364-371
Main Authors: CAVALETTI, G, TREDICI, G, MARMIROLI, P, PETRUCCIOLI, M. G, BARAJON, I, FABBRICA, D
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Nucleolus - drug effects
Cell Nucleolus - ultrastructure
Cisplatin - toxicity
Drug toxicity and drugs side effects treatment
Female
Ganglia, Spinal - drug effects
Ganglia, Spinal - ultrastructure
Histocytochemistry
Image Processing, Computer-Assisted
Medical sciences
Myelin Sheath - drug effects
Myelin Sheath - ultrastructure
Nerve Degeneration - drug effects
Neurons, Afferent - drug effects
Neurons, Afferent - ultrastructure
Peripheral Nerves - drug effects
Peripheral Nerves - ultrastructure
Peroneal Nerve - drug effects
Peroneal Nerve - ultrastructure
Pharmacology. Drug treatments
Rats
Rats, Wistar
Sciatic Nerve - drug effects
Sciatic Nerve - ultrastructure
Toxicity: nervous system and muscle
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We performed a morphological, morphometric and toxicological study on the spinal ganglia and peripheral nerves of the rat after chronic administration of cisplatin (cis-dichlorodiammineplatinum II; DDP) with two different schedules. Severe damage of the spinal ganglia neurons was demonstrated with predominant involvement of the nucleus and nucleolus associated with a decrease in the cell size. Morphological and morphometric changes also occurred in the sciatic and peroneal nerves with the features of axonopathy. All these changes were more marked in the group of rats which underwent the most intense DDP treatment and the tissue platinum concentrations were also higher in this group. This experimental model is the first available for chronic DDP administration in which concomitant spinal ganglia and peripheral nerve damage has been confirmed pathologically. Our study supports the hypothesis that DDP-induced peripheral nerve fiber degeneration may result from nuclear and nucleolar changes in the sensory ganglion cell perikaryon.
ISSN:0001-6322
1432-0533
DOI:10.1007/BF00227662