Immunocytochemical and ultrastructural evidence of dendritic degeneration in motor neurons of aluminum-intoxicated rabbits

Using immunocytochemical and ultrastructural methods, we observed extensive and characteristic dendritic changes in motor neurons of rabbits inoculated intracisternally with aluminum phosphate. Anti-microtubule-associated protein 2 immunostaining revealed markedly reduced immunoreactivity in motor n...

Full description

Saved in:
Bibliographic Details
Published in:Acta neuropathologica 1993, Vol.85 (2), p.122-128
Main Authors: WAKAYAMA, I, NERURKAR, V. R, GARRUTO, R. M
Format: Article
Language:English
Subjects:
Aluminum - toxicity
Aluminum Compounds
Animals
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Dendrites - chemistry
Dendrites - drug effects
Dendrites - ultrastructure
Female
Immunoenzyme Techniques
Medical sciences
Metals and various inorganic compounds
Microscopy, Electron
Motor Neurons - chemistry
Motor Neurons - drug effects
Motor Neurons - ultrastructure
Nerve Degeneration - drug effects
Nerve Tissue Proteins - analysis
Phosphates - toxicity
Rabbits
Toxicology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Using immunocytochemical and ultrastructural methods, we observed extensive and characteristic dendritic changes in motor neurons of rabbits inoculated intracisternally with aluminum phosphate. Anti-microtubule-associated protein 2 immunostaining revealed markedly reduced immunoreactivity in motor neuron dendrites and a reduced number of dendritic trees in aluminum phosphate-intoxicated rabbits. These dendritic changes were confirmed at the ultrastructural level; neurofilamentous accumulations, membranous inclusions and disrupted microtubules were common features of motor neuron axons. These observations suggest that dendrites are characteristically involved in aluminum intoxication in addition to the widely reported accumulation of phosphorylated neurofilament in perikarya and axons.
ISSN:0001-6322
1432-0533
DOI:10.1007/BF00227758