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The preparation and characterisation of 111In-labelled 791T/36 monoclonal antibody for tumour immunoscintigraphy

The anti-human tumour monoclonal antibody 791T/36 was conjugated to the cyclic dianhydride of DTPA and radio-labelled with 111In. The labelling method proved to be both simple and reliable and would be suitable for routine clinical use. Subsequent characterisation of this radio-pharmaceutical in vit...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 1985, Vol.10 (7-8), p.296-301
Main Authors: PERKINS, A. C, PIMM, M. V, BIRCH, M. K
Format: Article
Language:English
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Summary:The anti-human tumour monoclonal antibody 791T/36 was conjugated to the cyclic dianhydride of DTPA and radio-labelled with 111In. The labelling method proved to be both simple and reliable and would be suitable for routine clinical use. Subsequent characterisation of this radio-pharmaceutical in vitro and in tumour-bearing hosts gave a strong indication as to its suitability for clinical tumour localisation studies.
ISSN:0340-6997
1619-7089
DOI:10.1007/BF00251299