Uptake of 11C-L- and D-methionine in brain tumors

11C-labeled L- and D-methionine uptake was measured in seven patients with brain tumors using positron emission tomography. Tumors accumulated both isomers of the tracer. The strongest uptake occurred in tumors with a high grade of malignancy, while low grade tumors accumulated less activity. The L...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 1985, Vol.10 (7-8), p.373-376
Main Authors: MEYER, G.-J, SCHOBER, O, HUNDESHAGEN, H
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - metabolism
Carbon Radioisotopes
Humans
Isomerism
Medical sciences
Methionine - metabolism
Neurology
Tomography, Emission-Computed
Tumors of the nervous system. Phacomatoses
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Summary:11C-labeled L- and D-methionine uptake was measured in seven patients with brain tumors using positron emission tomography. Tumors accumulated both isomers of the tracer. The strongest uptake occurred in tumors with a high grade of malignancy, while low grade tumors accumulated less activity. The L to D uptake ratio in tumor regions ranged from 0.92-1.25. Conventional 99mTc-DTPA scans revealed blood-brain barrier damage in two patients with no or only slight 11C-methionine accumulation, while one patient with a negative 99mTc-DTPA scan accumulated 11C-methionine in the tumor region. In view of the biochemical pathway of methionine and the present findings, it is concluded that the uptake reflects metabolic activity in brain tissue rather than uptake by diffusion due to disruption of the blood-brain barrier.
ISSN:0340-6997
1619-7089
DOI:10.1007/BF00251316