Efficacy of 15-(123I)-p-iodophenyl pentadecanoic acid (IPPA) in assessing myocardial metabolism in a model of reversible global ischemia

In a canine model of reversible global ischemia, the residual quantity of 123I was assessed following a bolus injection of 15-p-(123I)-iodophenyl pentadecanoic acid (123I-IPPA). This technique was used to assess changes in free fatty acid metabolism following the utilization of three cardioplegic fo...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 1988-12, Vol.14 (12), p.594-599, Article 594
Main Authors: Hudon, M P, Lyster, D M, Jamieson, E W, Qayumi, K A, Kiess, M C, Rosado, L J, Autor, A P, Sartori, C, Dougan, H, van den Broek, J
Format: Article
Language:English
Subjects:
Animals
Cardioplegic Solutions - pharmacology
Coronary Disease - diagnostic imaging
Coronary Disease - metabolism
Dogs
Heart - diagnostic imaging
Heart Arrest, Induced
Iodine Radioisotopes
Iodobenzenes
Myocardium - metabolism
Radionuclide Imaging
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Summary:In a canine model of reversible global ischemia, the residual quantity of 123I was assessed following a bolus injection of 15-p-(123I)-iodophenyl pentadecanoic acid (123I-IPPA). This technique was used to assess changes in free fatty acid metabolism following the utilization of three cardioplegic formulations. Cardioplegic arrest was initiated with Tyers' iso-osmolar (IO) solution (Group A); IO + superoxide dismutase (SOD) (Group B) and IO + allopurinol (Group C). Pre and post operative scanning were completed with 2-5 mCi 123I-IPPA. Clearance was assessed by IPPA time activity curve analysis generating t1/2 (half lives in min) for the early and late phases of the curve. The assessment between groups demonstrated that the elimination of 123I-IPPA products (early phase) was faster from the lateral wall in groups B and C versus group A (14 +/- 12 min, 13 +/- 9 min and 24 +/- 10 min, respectively). The elimination of IPPA (late phase) was also faster from the lateral wall in groups B and C when compared to group A (240 +/- 270 min, 132 +/- 85 min and 416 +/- 238 min). Examining the changes between control and postoperative values for each area of the left ventricle within each group demonstrated no significant changes for groups B and C. Group A, however, demonstrated significantly increased t1/2 values for the lateral wall (early and late phases) and the apical wall (late phase).
ISSN:0340-6997
1619-7089
DOI:10.1007/BF00251782