'Variant' angina: evidence for small vessel coronary artery spasm?

A unique case of 'variant' angina pectoris has been observed in a patient with normal coronary arteries and typical chest pain appearing spontaneously at rest, and repeatedly provoked by ergonovine maleate (0.1 mg iv) associated with large transmural perfusion defects on 201Tl-imaging (aft...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 1980-12, Vol.5 (6), p.529-533
Main Authors: Pfisterer, M, Müller-Brand, J, Cueni, T, Lütold, B, Burkart, F
Format: Article
Language:English
Subjects:
Adult
Angina Pectoris - physiopathology
Angina Pectoris, Variant - diagnosis
Angina Pectoris, Variant - diagnostic imaging
Angina Pectoris, Variant - physiopathology
Coronary Vessels - physiopathology
Electrocardiography
Heart - diagnostic imaging
Humans
Male
Radionuclide Imaging
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Summary:A unique case of 'variant' angina pectoris has been observed in a patient with normal coronary arteries and typical chest pain appearing spontaneously at rest, and repeatedly provoked by ergonovine maleate (0.1 mg iv) associated with large transmural perfusion defects on 201Tl-imaging (after ergonovine) and a marked increase in T wave voltage despite no demonstrable spasm of a major coronary artery after the same doses of ergonovine. While saline solution could not provoke chest pain and treatment with a beta-blocking agent increased the frequency of ischemic attacks, a calcium antagonist therapy reduced and eventually eliminated the attacks. Thus, this case provides evidence for yet another aspect of a 'variant' form of angina pectoris: small vessel coronary artery spasm.
ISSN:0340-6997
1619-7089
DOI:10.1007/BF00252044