Thyroid uptake of MIBG in Sipplés syndrome

The use of the adrenomedullary tracer metaiodobenzylguanidine (MIBG) in the localization of medullary carcinoma of the thyroid (MCT) is based on the embryologic relationship of the APUD cell series. The authors report the results obtained in six patients with MCT: two had Sipple's syndrome and...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 1988-04, Vol.14 (1), p.37-38
Main Authors: PERDRISOT, R, ROHMER, V, LEJEUNE, J. J, BIGORGNE, J. C, JALLET, P
Format: Article
Language:English
Subjects:
3-Iodobenzylguanidine
Adult
Aged
Biological and medical sciences
Carcinoma - diagnostic imaging
Endocrinopathies
Female
Humans
Iodine Radioisotopes
Iodobenzenes
Male
Malignant tumors
Medical sciences
Middle Aged
Multiple Endocrine Neoplasia - diagnostic imaging
Multiple Endocrine Neoplasia - genetics
Radionuclide Imaging
Thyroid Neoplasms - diagnostic imaging
Thyroid. Thyroid axis (diseases)
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Summary:The use of the adrenomedullary tracer metaiodobenzylguanidine (MIBG) in the localization of medullary carcinoma of the thyroid (MCT) is based on the embryologic relationship of the APUD cell series. The authors report the results obtained in six patients with MCT: two had Sipple's syndrome and four sporadic forms of the disease. MIBG uptake by the CMT was observed in both cases of Sipple's syndrome and in only one of the other cases. Scintigraphic detection seems to depend on the clinical features, the size of the tumour and also on the part played by its secretory function. MCT would thus appear to be more frequently visualized by MIBG in cases of Sipple's syndrome than in sporadic cases. The procedure therefore seems useful in the diagnosis, follow up and even in the treatment of MCT.
ISSN:0340-6997
1619-7089
DOI:10.1007/BF00252616